5D3P
First bromodomain of BRD4 bound to inhibitor XD41
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 1 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (Human) | Protein HUNK1 |
| 2 | B (A) | 1-[(4-acetyl-3-ethyl-5-methyl-1H-pyrrol-2-yl)carbonyl]-N-methyl-1H-indole-6-sulfonamide | non-polymer | 387.5 | 1 | Chemie (57E) | |||
| 3 | C (A) | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
| 4 | D (A) | water | water | 18.0 | 142 | Chemie (HOH) |
Sequence modifications
A: 42 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Met 43 | Thr 43 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15099.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 446.1 | |
| All* | Total formula weight | 15545.5 |
