5D26
First bromodomain of BRD4 bound to inhibitor XD28
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 1 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (Human) | Protein HUNK1 |
2 | A | N~2~-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2,4-dicarboxamide | non-polymer | 422.5 | 1 | Chemie (L28) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
4 | A | (R,R)-2,3-BUTANEDIOL | non-polymer | 90.1 | 1 | Chemie (BU3) | |||
5 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
6 | water | water | 18.0 | 167 | Chemie (HOH) |
Sequence modifications
A: 42 - 168 (UniProt: O60885)
PDB | External Database | Details |
---|---|---|
Met 43 | Thr 43 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 15099.4 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 597.7 | |
All* | Total formula weight | 15697.1 |