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5D26

First bromodomain of BRD4 bound to inhibitor XD28

Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue L28 A 201
ChainResidue
AGLN59
AHOH317
AHOH321
AHOH338
AHOH407
AHOH431
ATRP81
APRO82
AGLN85
AVAL87
ALYS91
ALEU92
AASN140
AILE146

site_idAC2
Number of Residues4
Detailsbinding site for residue EDO A 202
ChainResidue
AASP145
AHOH314
AHOH333
AHOH342

site_idAC3
Number of Residues7
Detailsbinding site for residue BU3 A 203
ChainResidue
AGLN59
AGLN64
ALEU114
AASN117
AHOH315
AHOH327
AHOH427

site_idAC4
Number of Residues6
Detailsbinding site for residue NA A 204
ChainResidue
AHOH342
AHOH385
AHOH404
AHOH413
AHOH433
AHOH461

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

227111

PDB entries from 2024-11-06

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