5D25
First bromodomain of BRD4 bound to inhibitor XD27
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Bromodomain-containing protein 4 | polymer | 126 | 15012.3 | 1 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (Human) | Protein HUNK1 |
2 | A | 4-acetyl-N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3,5-dimethyl-1H-pyrrole-2-carboxamide | non-polymer | 407.5 | 1 | Chemie (56M) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
4 | A | (R,R)-2,3-BUTANEDIOL | non-polymer | 90.1 | 1 | Chemie (BU3) | |||
5 | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A: 43 - 168 (UniProt: O60885)
PDB | External Database | Details |
---|---|---|
Met 43 | Thr 43 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 15012.3 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 589.7 | |
All* | Total formula weight | 15602.0 |