5D25

First bromodomain of BRD4 bound to inhibitor XD27

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue 56M A 201

Chain	Residue
A	GLN59
A	GOL202
A	BU3203
A	HOH317
A	HOH323
A	HOH327
A	HOH379
A	PRO82
A	GLN85
A	VAL87
A	LYS91
A	LEU92
A	ASN117
A	ASN140
A	ILE146

---

site_id	AC2
Number of Residues	3
Details	binding site for residue GOL A 202

Chain	Residue
A	ASP145
A	56M201
A	HOH360

---

site_id	AC3
Number of Residues	7
Details	binding site for residue BU3 A 203

Chain	Residue
A	GLN59
A	GLN64
A	LEU114
A	ASN117
A	56M201
A	HOH305
A	HOH364

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	106
Details	Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---