5CXY
Structure of a Glycosyltransferase in Complex with Inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase | polymer | 323 | 37919.0 | 2 | UniProt (O43173) Pfam (PF00777) In PDB | Homo sapiens (Human) | Alpha-2,8-sialyltransferase 8C,8-sialyltransferase III,ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3,Sialyltransferase 8C,SIAT8-C,Sialyltransferase St8Sia III,ST8SiaIII |
2 | C | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
3 | D, F, G, H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
4 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
5 | A, B | 5'-O-[(R)-[(S)-[3-(acetylamino)phenyl](phosphono)methoxy](hydroxy)phosphoryl]cytidine | non-polymer | 550.4 | 2 | Chemie (55T) | |||
6 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
7 | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A, B: 81 - 380 (UniProt: O43173)
PDB | External Database | Details |
---|---|---|
Ala 58 | - | expression tag |
Pro 59 | - | expression tag |
Glu 60 | - | expression tag |
His 61 | - | expression tag |
His 62 | - | expression tag |
His 63 | - | expression tag |
His 64 | - | expression tag |
His 65 | - | expression tag |
His 66 | - | expression tag |
Asp 67 | - | expression tag |
Tyr 68 | - | expression tag |
Asp 69 | - | expression tag |
Ile 70 | - | expression tag |
Pro 71 | - | expression tag |
Thr 72 | - | expression tag |
Thr 73 | - | expression tag |
Glu 74 | - | expression tag |
Asn 75 | - | expression tag |
Leu 76 | - | expression tag |
Tyr 77 | - | expression tag |
Phe 78 | - | expression tag |
Gln 79 | - | expression tag |
Gly 80 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 75838.0 | |
Branched | Number of molecules | 6 |
Total formula weight | 2854.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1543.1 | |
All* | Total formula weight | 80235.8 |