5CTT

Crystal structure of human SART3/TIP110 NLS-mouse importin alpha complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Importin subunit alpha-1	polymer	447	48446.4	1	UniProt (P52293) Pfam (PF01749) Pfam (PF00514) Pfam (PF16186)	Mus musculus (Mouse)	Importin alpha P1,Karyopherin subunit alpha-2,Pendulin,Pore targeting complex 58 kDa subunit,PTAC58,RAG cohort protein 1,SRP1-alpha
2	B (B)	Squamous cell carcinoma antigen recognized by T-cells 3	polymer	55	6535.4	1	UniProt (Q15020)	Homo sapiens (Human)	SART-3,Tat-interacting protein of 110 kDa,Tip110,p110 nuclear RNA-binding protein
3	C, D (A, B)	water	water		18.0	472	Chemie (HOH)

Sequence modifications

A: 72 - 497 (UniProt: P52293)

PDB	External Database	Details
Met 51	-	initiating methionine
Gly 52	-	expression tag
Ser 53	-	expression tag
Ser 54	-	expression tag
His 55	-	expression tag
His 56	-	expression tag
His 57	-	expression tag
His 58	-	expression tag
His 59	-	expression tag
His 60	-	expression tag
Ser 61	-	expression tag
Ser 62	-	expression tag
Gly 63	-	expression tag
Leu 64	-	expression tag
Val 65	-	expression tag
Pro 66	-	expression tag
Arg 67	-	expression tag
Gly 68	-	expression tag
Ser 69	-	expression tag
His 70	-	expression tag
Met 71	-	expression tag

B: 601 - 649 (UniProt: Q15020)

PDB	External Database	Details
Leu 595	-	expression tag
Val 596	-	expression tag
Pro 597	-	expression tag
Arg 598	-	expression tag
Gly 599	-	expression tag
Ser 600	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	54981.8
All*	Total formula weight	54981.8

*Water molecules are not included.