5CSX
CRYSTAL STRUCTURE OF B-RAF IN COMPLEX WITH BI 882370
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase B-raf | polymer | 282 | 32029.7 | 1 | UniProt (P15056) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | B (A) | N-(3-{5-[(1-ethylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamide | non-polymer | 569.7 | 1 | Chemie (54J) | |||
| 3 | C (A) | alpha-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (GLC) | |||
| 4 | D (A) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A: 442 - 721 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Pro 443 | Arg 443 | engineered mutation |
| Ala 543 | Ile 543 | engineered mutation |
| Ser 544 | Ile 544 | engineered mutation |
| Lys 551 | Ile 551 | engineered mutation |
| Arg 562 | Gln 562 | engineered mutation |
| Asn 588 | Leu 588 | engineered mutation |
| Ser 630 | Lys 630 | engineered mutation |
| Glu 667 | Phe 667 | engineered mutation |
| Ser 673 | Tyr 673 | engineered mutation |
| Arg 688 | Ala 688 | engineered mutation |
| Ser 706 | Leu 706 | engineered mutation |
| Arg 709 | Gln 709 | engineered mutation |
| Glu 713 | Ser 713 | engineered mutation |
| Glu 716 | Leu 716 | engineered mutation |
| Glu 720 | Ser 720 | engineered mutation |
| Ser 722 | - | expression tag |
| Gly 723 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32029.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 749.8 | |
| All* | Total formula weight | 32779.5 |
