5CPR
The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Histone-lysine N-methyltransferase SUV420H1 | polymer | 268 | 30925.0 | 1 | UniProt (Q4FZB7) Pfam (PF00856) In PDB | Homo sapiens (Human) | Lysine N-methyltransferase 5B,Suppressor of variegation 4-20 homolog 1,Suv4-20h1 |
| 2 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | B | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
| 4 | B | 6,7-dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine | non-polymer | 359.3 | 1 | Chemie (539) | |||
| 5 | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
B: 69 - 335 (UniProt: Q4FZB7)
| PDB | External Database | Details |
|---|---|---|
| Gly 68 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30925.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 823.1 | |
| All* | Total formula weight | 31748.1 |
