5CPR
The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Histone-lysine N-methyltransferase SUV420H1 | polymer | 268 | 30925.0 | 1 | UniProt (Q4FZB7) Pfam (PF00856) | Homo sapiens (Human) | Lysine N-methyltransferase 5B,Suppressor of variegation 4-20 homolog 1,Suv4-20h1 |
| 2 | B (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (9865603) PubChem (12312798) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (145712080) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) | |||
| 4 | D (B) | 6,7-dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine | non-polymer | 359.3 | 1 | Chemie (539) PubChem (117072548) | |||
| 5 | E (B) | water | water | 18.0 | 144 | Chemie (HOH) |
Sequence modifications
B: 69 - 335 (UniProt: Q4FZB7)
| PDB | External Database | Details |
|---|---|---|
| Gly 68 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30925.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 823.1 | |
| All* | Total formula weight | 31748.1 |
