5CPR
The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0042799 | molecular_function | histone H4K20 methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 401 |
| Chain | Residue |
| B | CYS275 |
| B | CYS319 |
| B | CYS321 |
| B | CYS324 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue SAM B 402 |
| Chain | Residue |
| B | ALA210 |
| B | PHE250 |
| B | ARG257 |
| B | ALA269 |
| B | PHE270 |
| B | ILE271 |
| B | ASN272 |
| B | HIS273 |
| B | TYR307 |
| B | PHE312 |
| B | CYS319 |
| B | GLU320 |
| B | CYS321 |
| B | HOH531 |
| B | HIS98 |
| B | TYR203 |
| B | SER205 |
| B | GLU206 |
| B | GLY209 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue 539 B 403 |
| Chain | Residue |
| B | GLY229 |
| B | ARG244 |
| B | SER251 |
| B | VAL252 |
| B | TRP264 |
| B | ALA268 |
| B | ALA269 |
| B | PHE281 |
| B | SER283 |
| B | ALA289 |
| B | TYR307 |
| B | HOH524 |
| B | HOH551 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273, ECO:0000269|Ref.14, ECO:0007744|PDB:3S8P, ECO:0007744|PDB:5CPR, ECO:0007744|PDB:5WBV |
| Chain | Residue | Details |
| B | HIS98 | |
| B | TYR203 | |
| B | ALA210 | |
| B | ASN272 | |
| B | CYS275 | |
| B | CYS319 | |
| B | GLU320 | |
| B | CYS321 | |
| B | CYS324 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24396869, ECO:0000269|PubMed:28114273, ECO:0007744|PDB:3S8P, ECO:0007744|PDB:5CPR |
| Chain | Residue | Details |
| B | ARG257 |
