5CNO
Crystal structure of the EGFR kinase domain mutant V924R
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, X) | Epidermal growth factor receptor | polymer | 330 | 37621.5 | 3 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | D, F (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 3 | E, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | H, I, J (A, B, X) | water | water | 18.0 | 541 | Chemie (HOH) |
Sequence modifications
A, B, X: 672 - 998 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 669 | - | expression tag |
| Ala 670 | - | expression tag |
| Met 671 | - | expression tag |
| Arg 924 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 112864.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1061.0 | |
| All* | Total formula weight | 113925.6 |
