5CJP

The Structural Basis for Cdc42-Induced Dimerization of IQGAPs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Cell division cycle 42 (GTP binding protein, 25kDa), isoform CRA_a	polymer	179	19758.7	4	UniProt (A0A024RAE4) Pfam (PF00071) UniProt (by SIFTS) (P60953) In PDB	Homo sapiens (Human)
2	E, F	Ras GTPase-activating-like protein IQGAP2	polymer	387	44058.1	2	UniProt (Q13576) Pfam (PF00616) In PDB	Homo sapiens (Human)
3	A, B, C, D	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	4	Chemie (GTP)
4	A, B, C, D	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
5		water	water		18.0	118	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 177 (UniProt: A0A024RAE4)

PDB	External Database	Details
Gly -1	-	expression tag
Ala 0	-	expression tag
Leu 61	Gln 61	engineered mutation

E, F: 875 - 1258 (UniProt: Q13576)

PDB	External Database	Details
Gly 872	-	expression tag
Ala 873	-	expression tag
Met 874	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	167151.2
Non-Polymers*	Number of molecules	8
	Total formula weight	2189.9
All*	Total formula weight	169341.1

*Water molecules are not included.