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5CJP

The Structural Basis for Cdc42-Induced Dimerization of IQGAPs

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0000322cellular_componentstorage vacuole
A0002040biological_processsprouting angiogenesis
A0003015biological_processheart process
A0003161biological_processcardiac conduction system development
A0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0005925cellular_componentfocal adhesion
A0006897biological_processendocytosis
A0006911biological_processphagocytosis, engulfment
A0007015biological_processactin filament organization
A0007030biological_processGolgi organization
A0007088biological_processregulation of mitotic nuclear division
A0007097biological_processnuclear migration
A0007163biological_processestablishment or maintenance of cell polarity
A0007229biological_processintegrin-mediated signaling pathway
A0007264biological_processsmall GTPase-mediated signal transduction
A0007399biological_processnervous system development
A0008104biological_processprotein localization
A0009653biological_processanatomical structure morphogenesis
A0010591biological_processregulation of lamellipodium assembly
A0010592biological_processpositive regulation of lamellipodium assembly
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0017119cellular_componentGolgi transport complex
A0019901molecular_functionprotein kinase binding
A0021762biological_processsubstantia nigra development
A0030036biological_processactin cytoskeleton organization
A0030141cellular_componentsecretory granule
A0030154biological_processcell differentiation
A0030175cellular_componentfilopodium
A0030225biological_processmacrophage differentiation
A0030307biological_processpositive regulation of cell growth
A0030335biological_processpositive regulation of cell migration
A0030425cellular_componentdendrite
A0030496cellular_componentmidbody
A0030742molecular_functionGTP-dependent protein binding
A0031252cellular_componentcell leading edge
A0031256cellular_componentleading edge membrane
A0031274biological_processpositive regulation of pseudopodium assembly
A0031333biological_processnegative regulation of protein-containing complex assembly
A0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
A0031996molecular_functionthioesterase binding
A0032427molecular_functionGBD domain binding
A0032467biological_processpositive regulation of cytokinesis
A0032488biological_processCdc42 protein signal transduction
A0032956biological_processregulation of actin cytoskeleton organization
A0032991cellular_componentprotein-containing complex
A0034191molecular_functionapolipoprotein A-I receptor binding
A0034329biological_processcell junction assembly
A0034332biological_processadherens junction organization
A0035050biological_processembryonic heart tube development
A0035088biological_processestablishment or maintenance of apical/basal cell polarity
A0036336biological_processdendritic cell migration
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0038189biological_processneuropilin signaling pathway
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0043227cellular_componentmembrane-bounded organelle
A0043410biological_processpositive regulation of MAPK cascade
A0043525biological_processpositive regulation of neuron apoptotic process
A0044788biological_processmodulation by host of viral process
A0045177cellular_componentapical part of cell
A0045198biological_processestablishment of epithelial cell apical/basal polarity
A0045335cellular_componentphagocytic vesicle
A0045740biological_processpositive regulation of DNA replication
A0046330biological_processpositive regulation of JNK cascade
A0046847biological_processfilopodium assembly
A0048549biological_processpositive regulation of pinocytosis
A0048664biological_processneuron fate determination
A0051130biological_processpositive regulation of cellular component organization
A0051233cellular_componentspindle midzone
A0051489biological_processregulation of filopodium assembly
A0051491biological_processpositive regulation of filopodium assembly
A0051492biological_processregulation of stress fiber assembly
A0051496biological_processpositive regulation of stress fiber assembly
A0051647biological_processnucleus localization
A0051649biological_processestablishment of localization in cell
A0051683biological_processestablishment of Golgi localization
A0051835biological_processpositive regulation of synapse structural plasticity
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051988biological_processregulation of attachment of spindle microtubules to kinetochore
A0060047biological_processheart contraction
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
A0060661biological_processsubmandibular salivary gland formation
A0060997biological_processdendritic spine morphogenesis
A0061630molecular_functionubiquitin protein ligase activity
A0070062cellular_componentextracellular exosome
A0071346biological_processcellular response to type II interferon
A0071944cellular_componentcell periphery
A0072384biological_processorganelle transport along microtubule
A0072686cellular_componentmitotic spindle
A0086101biological_processendothelin receptor signaling pathway involved in heart process
A0090135biological_processactin filament branching
A0090316biological_processpositive regulation of intracellular protein transport
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098978cellular_componentglutamatergic synapse
A0099159biological_processregulation of modification of postsynaptic structure
A0099175biological_processregulation of postsynapse organization
A0099563biological_processmodification of synaptic structure
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000322cellular_componentstorage vacuole
B0002040biological_processsprouting angiogenesis
B0003015biological_processheart process
B0003161biological_processcardiac conduction system development
B0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0005925cellular_componentfocal adhesion
B0006897biological_processendocytosis
B0006911biological_processphagocytosis, engulfment
B0007015biological_processactin filament organization
B0007030biological_processGolgi organization
B0007088biological_processregulation of mitotic nuclear division
B0007097biological_processnuclear migration
B0007163biological_processestablishment or maintenance of cell polarity
B0007229biological_processintegrin-mediated signaling pathway
B0007264biological_processsmall GTPase-mediated signal transduction
B0007399biological_processnervous system development
B0008104biological_processprotein localization
B0009653biological_processanatomical structure morphogenesis
B0010591biological_processregulation of lamellipodium assembly
B0010592biological_processpositive regulation of lamellipodium assembly
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0017119cellular_componentGolgi transport complex
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0030036biological_processactin cytoskeleton organization
B0030141cellular_componentsecretory granule
B0030154biological_processcell differentiation
B0030175cellular_componentfilopodium
B0030225biological_processmacrophage differentiation
B0030307biological_processpositive regulation of cell growth
B0030335biological_processpositive regulation of cell migration
B0030425cellular_componentdendrite
B0030496cellular_componentmidbody
B0030742molecular_functionGTP-dependent protein binding
B0031252cellular_componentcell leading edge
B0031256cellular_componentleading edge membrane
B0031274biological_processpositive regulation of pseudopodium assembly
B0031333biological_processnegative regulation of protein-containing complex assembly
B0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
B0031996molecular_functionthioesterase binding
B0032427molecular_functionGBD domain binding
B0032467biological_processpositive regulation of cytokinesis
B0032488biological_processCdc42 protein signal transduction
B0032956biological_processregulation of actin cytoskeleton organization
B0032991cellular_componentprotein-containing complex
B0034191molecular_functionapolipoprotein A-I receptor binding
B0034329biological_processcell junction assembly
B0034332biological_processadherens junction organization
B0035050biological_processembryonic heart tube development
B0035088biological_processestablishment or maintenance of apical/basal cell polarity
B0036336biological_processdendritic cell migration
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0038189biological_processneuropilin signaling pathway
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0043227cellular_componentmembrane-bounded organelle
B0043410biological_processpositive regulation of MAPK cascade
B0043525biological_processpositive regulation of neuron apoptotic process
B0044788biological_processmodulation by host of viral process
B0045177cellular_componentapical part of cell
B0045198biological_processestablishment of epithelial cell apical/basal polarity
B0045335cellular_componentphagocytic vesicle
B0045740biological_processpositive regulation of DNA replication
B0046330biological_processpositive regulation of JNK cascade
B0046847biological_processfilopodium assembly
B0048549biological_processpositive regulation of pinocytosis
B0048664biological_processneuron fate determination
B0051130biological_processpositive regulation of cellular component organization
B0051233cellular_componentspindle midzone
B0051489biological_processregulation of filopodium assembly
B0051491biological_processpositive regulation of filopodium assembly
B0051492biological_processregulation of stress fiber assembly
B0051496biological_processpositive regulation of stress fiber assembly
B0051647biological_processnucleus localization
B0051649biological_processestablishment of localization in cell
B0051683biological_processestablishment of Golgi localization
B0051835biological_processpositive regulation of synapse structural plasticity
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051988biological_processregulation of attachment of spindle microtubules to kinetochore
B0060047biological_processheart contraction
B0060071biological_processWnt signaling pathway, planar cell polarity pathway
B0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
B0060661biological_processsubmandibular salivary gland formation
B0060997biological_processdendritic spine morphogenesis
B0061630molecular_functionubiquitin protein ligase activity
B0070062cellular_componentextracellular exosome
B0071346biological_processcellular response to type II interferon
B0071944cellular_componentcell periphery
B0072384biological_processorganelle transport along microtubule
B0072686cellular_componentmitotic spindle
B0086101biological_processendothelin receptor signaling pathway involved in heart process
B0090135biological_processactin filament branching
B0090316biological_processpositive regulation of intracellular protein transport
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098978cellular_componentglutamatergic synapse
B0099159biological_processregulation of modification of postsynaptic structure
B0099175biological_processregulation of postsynapse organization
B0099563biological_processmodification of synaptic structure
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C0000139cellular_componentGolgi membrane
C0000166molecular_functionnucleotide binding
C0000322cellular_componentstorage vacuole
C0002040biological_processsprouting angiogenesis
C0003015biological_processheart process
C0003161biological_processcardiac conduction system development
C0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005911cellular_componentcell-cell junction
C0005925cellular_componentfocal adhesion
C0006897biological_processendocytosis
C0006911biological_processphagocytosis, engulfment
C0007015biological_processactin filament organization
C0007030biological_processGolgi organization
C0007088biological_processregulation of mitotic nuclear division
C0007097biological_processnuclear migration
C0007163biological_processestablishment or maintenance of cell polarity
C0007229biological_processintegrin-mediated signaling pathway
C0007264biological_processsmall GTPase-mediated signal transduction
C0007399biological_processnervous system development
C0008104biological_processprotein localization
C0009653biological_processanatomical structure morphogenesis
C0010591biological_processregulation of lamellipodium assembly
C0010592biological_processpositive regulation of lamellipodium assembly
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0017119cellular_componentGolgi transport complex
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030036biological_processactin cytoskeleton organization
C0030141cellular_componentsecretory granule
C0030154biological_processcell differentiation
C0030175cellular_componentfilopodium
C0030225biological_processmacrophage differentiation
C0030307biological_processpositive regulation of cell growth
C0030335biological_processpositive regulation of cell migration
C0030425cellular_componentdendrite
C0030496cellular_componentmidbody
C0030742molecular_functionGTP-dependent protein binding
C0031252cellular_componentcell leading edge
C0031256cellular_componentleading edge membrane
C0031274biological_processpositive regulation of pseudopodium assembly
C0031333biological_processnegative regulation of protein-containing complex assembly
C0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
C0031996molecular_functionthioesterase binding
C0032427molecular_functionGBD domain binding
C0032467biological_processpositive regulation of cytokinesis
C0032488biological_processCdc42 protein signal transduction
C0032956biological_processregulation of actin cytoskeleton organization
C0032991cellular_componentprotein-containing complex
C0034191molecular_functionapolipoprotein A-I receptor binding
C0034329biological_processcell junction assembly
C0034332biological_processadherens junction organization
C0035050biological_processembryonic heart tube development
C0035088biological_processestablishment or maintenance of apical/basal cell polarity
C0036336biological_processdendritic cell migration
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0038189biological_processneuropilin signaling pathway
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0043227cellular_componentmembrane-bounded organelle
C0043410biological_processpositive regulation of MAPK cascade
C0043525biological_processpositive regulation of neuron apoptotic process
C0044788biological_processmodulation by host of viral process
C0045177cellular_componentapical part of cell
C0045198biological_processestablishment of epithelial cell apical/basal polarity
C0045335cellular_componentphagocytic vesicle
C0045740biological_processpositive regulation of DNA replication
C0046330biological_processpositive regulation of JNK cascade
C0046847biological_processfilopodium assembly
C0048549biological_processpositive regulation of pinocytosis
C0048664biological_processneuron fate determination
C0051130biological_processpositive regulation of cellular component organization
C0051233cellular_componentspindle midzone
C0051489biological_processregulation of filopodium assembly
C0051491biological_processpositive regulation of filopodium assembly
C0051492biological_processregulation of stress fiber assembly
C0051496biological_processpositive regulation of stress fiber assembly
C0051647biological_processnucleus localization
C0051649biological_processestablishment of localization in cell
C0051683biological_processestablishment of Golgi localization
C0051835biological_processpositive regulation of synapse structural plasticity
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0051988biological_processregulation of attachment of spindle microtubules to kinetochore
C0060047biological_processheart contraction
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
C0060661biological_processsubmandibular salivary gland formation
C0060997biological_processdendritic spine morphogenesis
C0061630molecular_functionubiquitin protein ligase activity
C0070062cellular_componentextracellular exosome
C0071346biological_processcellular response to type II interferon
C0071944cellular_componentcell periphery
C0072384biological_processorganelle transport along microtubule
C0072686cellular_componentmitotic spindle
C0086101biological_processendothelin receptor signaling pathway involved in heart process
C0090135biological_processactin filament branching
C0090316biological_processpositive regulation of intracellular protein transport
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098978cellular_componentglutamatergic synapse
C0099159biological_processregulation of modification of postsynaptic structure
C0099175biological_processregulation of postsynapse organization
C0099563biological_processmodification of synaptic structure
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
D0000139cellular_componentGolgi membrane
D0000166molecular_functionnucleotide binding
D0000322cellular_componentstorage vacuole
D0002040biological_processsprouting angiogenesis
D0003015biological_processheart process
D0003161biological_processcardiac conduction system development
D0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005789cellular_componentendoplasmic reticulum membrane
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005911cellular_componentcell-cell junction
D0005925cellular_componentfocal adhesion
D0006897biological_processendocytosis
D0006911biological_processphagocytosis, engulfment
D0007015biological_processactin filament organization
D0007030biological_processGolgi organization
D0007088biological_processregulation of mitotic nuclear division
D0007097biological_processnuclear migration
D0007163biological_processestablishment or maintenance of cell polarity
D0007229biological_processintegrin-mediated signaling pathway
D0007264biological_processsmall GTPase-mediated signal transduction
D0007399biological_processnervous system development
D0008104biological_processprotein localization
D0009653biological_processanatomical structure morphogenesis
D0010591biological_processregulation of lamellipodium assembly
D0010592biological_processpositive regulation of lamellipodium assembly
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0017119cellular_componentGolgi transport complex
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0030036biological_processactin cytoskeleton organization
D0030141cellular_componentsecretory granule
D0030154biological_processcell differentiation
D0030175cellular_componentfilopodium
D0030225biological_processmacrophage differentiation
D0030307biological_processpositive regulation of cell growth
D0030335biological_processpositive regulation of cell migration
D0030425cellular_componentdendrite
D0030496cellular_componentmidbody
D0030742molecular_functionGTP-dependent protein binding
D0031252cellular_componentcell leading edge
D0031256cellular_componentleading edge membrane
D0031274biological_processpositive regulation of pseudopodium assembly
D0031333biological_processnegative regulation of protein-containing complex assembly
D0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
D0031996molecular_functionthioesterase binding
D0032427molecular_functionGBD domain binding
D0032467biological_processpositive regulation of cytokinesis
D0032488biological_processCdc42 protein signal transduction
D0032956biological_processregulation of actin cytoskeleton organization
D0032991cellular_componentprotein-containing complex
D0034191molecular_functionapolipoprotein A-I receptor binding
D0034329biological_processcell junction assembly
D0034332biological_processadherens junction organization
D0035050biological_processembryonic heart tube development
D0035088biological_processestablishment or maintenance of apical/basal cell polarity
D0036336biological_processdendritic cell migration
D0036464cellular_componentcytoplasmic ribonucleoprotein granule
D0038189biological_processneuropilin signaling pathway
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0043227cellular_componentmembrane-bounded organelle
D0043410biological_processpositive regulation of MAPK cascade
D0043525biological_processpositive regulation of neuron apoptotic process
D0044788biological_processmodulation by host of viral process
D0045177cellular_componentapical part of cell
D0045198biological_processestablishment of epithelial cell apical/basal polarity
D0045335cellular_componentphagocytic vesicle
D0045740biological_processpositive regulation of DNA replication
D0046330biological_processpositive regulation of JNK cascade
D0046847biological_processfilopodium assembly
D0048549biological_processpositive regulation of pinocytosis
D0048664biological_processneuron fate determination
D0051130biological_processpositive regulation of cellular component organization
D0051233cellular_componentspindle midzone
D0051489biological_processregulation of filopodium assembly
D0051491biological_processpositive regulation of filopodium assembly
D0051492biological_processregulation of stress fiber assembly
D0051496biological_processpositive regulation of stress fiber assembly
D0051647biological_processnucleus localization
D0051649biological_processestablishment of localization in cell
D0051683biological_processestablishment of Golgi localization
D0051835biological_processpositive regulation of synapse structural plasticity
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0051988biological_processregulation of attachment of spindle microtubules to kinetochore
D0060047biological_processheart contraction
D0060071biological_processWnt signaling pathway, planar cell polarity pathway
D0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
D0060661biological_processsubmandibular salivary gland formation
D0060997biological_processdendritic spine morphogenesis
D0061630molecular_functionubiquitin protein ligase activity
D0070062cellular_componentextracellular exosome
D0071346biological_processcellular response to type II interferon
D0071944cellular_componentcell periphery
D0072384biological_processorganelle transport along microtubule
D0072686cellular_componentmitotic spindle
D0086101biological_processendothelin receptor signaling pathway involved in heart process
D0090135biological_processactin filament branching
D0090316biological_processpositive regulation of intracellular protein transport
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098978cellular_componentglutamatergic synapse
D0099159biological_processregulation of modification of postsynaptic structure
D0099175biological_processregulation of postsynapse organization
D0099563biological_processmodification of synaptic structure
D1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
E0043087biological_processregulation of GTPase activity
F0043087biological_processregulation of GTPase activity
Functional Information from PDB Data
site_idAC1
Number of Residues23
Detailsbinding site for residue GTP A 201
ChainResidue
AGLY12
ATHR35
AGLY60
AGLN116
AASP118
ALEU119
AALA159
ALEU160
AMG202
AHOH301
AHOH307
AALA13
EASN928
EARG930
EGLU931
ETYR1197
AVAL14
AGLY15
ALYS16
ATHR17
ACYS18
ATYR32
APRO34

site_idAC2
Number of Residues6
Detailsbinding site for residue MG A 202
ChainResidue
ATHR17
ATHR35
AASP57
ATHR58
AGTP201
AHOH301

site_idAC3
Number of Residues23
Detailsbinding site for residue GTP B 201
ChainResidue
BGLY12
BALA13
BVAL14
BGLY15
BLYS16
BTHR17
BCYS18
BTYR32
BPRO34
BTHR35
BGLY60
BGLN116
BASP118
BLEU119
BALA159
BLEU160
BMG202
BHOH301
BHOH308
FASN928
FARG930
FGLU931
FTYR1197

site_idAC4
Number of Residues6
Detailsbinding site for residue MG B 202
ChainResidue
BTHR17
BTHR35
BASP57
BTHR58
BGTP201
BHOH301

site_idAC5
Number of Residues23
Detailsbinding site for residue GTP C 201
ChainResidue
CGLY12
CALA13
CVAL14
CGLY15
CLYS16
CTHR17
CCYS18
CPHE28
CTYR32
CPRO34
CTHR35
CGLY60
CGLN116
CASP118
CLEU119
CSER158
CALA159
CLEU160
CMG202
CHOH301
CHOH302
CHOH307
EGLN955

site_idAC6
Number of Residues6
Detailsbinding site for residue MG C 202
ChainResidue
CTHR17
CTHR35
CASP57
CTHR58
CGTP201
CHOH302

site_idAC7
Number of Residues20
Detailsbinding site for residue GTP D 201
ChainResidue
DGLN116
DASP118
DLEU119
DALA159
DLEU160
DMG202
DHOH303
FGLN955
DGLY12
DALA13
DVAL14
DGLY15
DLYS16
DTHR17
DCYS18
DPHE28
DTYR32
DPRO34
DTHR35
DGLY60

site_idAC8
Number of Residues5
Detailsbinding site for residue MG D 202
ChainResidue
DTHR17
DTHR35
DASP57
DTHR58
DGTP201

Functional Information from PROSITE/UniProt
site_idPS00509
Number of Residues15
DetailsRAS_GTPASE_ACTIV_1 Ras GTPase-activating proteins domain signature. NlLYYRYMNPAIVAP
ChainResidueDetails
EASN1102-PRO1116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING:
ChainResidueDetails
AGLY10
ATHR115
BGLY10
BTHR115
CGLY10
CTHR115
DGLY10
DTHR115

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP57
BASP57
CASP57
DASP57

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538, ECO:0000269|PubMed:20622875
ChainResidueDetails
ATYR32
BTYR32
CTYR32
DTYR32

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
ATHR35
BTHR35
CTHR35
DTHR35

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:14506284
ChainResidueDetails
ATYR64
BTYR64
CTYR64
DTYR64

site_idSWS_FT_FI6
Number of Residues4
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR32
BTYR32
CTYR32
DTYR32

site_idSWS_FT_FI7
Number of Residues4
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
ATHR35
BTHR35
CTHR35
DTHR35

218853

PDB entries from 2024-04-24

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