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5CJP

The Structural Basis for Cdc42-Induced Dimerization of IQGAPs

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0000322cellular_componentstorage vacuole
A0003015biological_processheart process
A0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0005925cellular_componentfocal adhesion
A0006897biological_processendocytosis
A0006911biological_processphagocytosis, engulfment
A0007015biological_processactin filament organization
A0007030biological_processGolgi organization
A0007163biological_processestablishment or maintenance of cell polarity
A0007165biological_processsignal transduction
A0007229biological_processintegrin-mediated signaling pathway
A0007264biological_processsmall GTPase-mediated signal transduction
A0007399biological_processnervous system development
A0009653biological_processanatomical structure morphogenesis
A0010591biological_processregulation of lamellipodium assembly
A0010592biological_processpositive regulation of lamellipodium assembly
A0015630cellular_componentmicrotubule cytoskeleton
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0017119cellular_componentGolgi transport complex
A0019901molecular_functionprotein kinase binding
A0021762biological_processsubstantia nigra development
A0030010biological_processestablishment of cell polarity
A0030036biological_processactin cytoskeleton organization
A0030154biological_processcell differentiation
A0030175cellular_componentfilopodium
A0030225biological_processmacrophage differentiation
A0030307biological_processpositive regulation of cell growth
A0030335biological_processpositive regulation of cell migration
A0030425cellular_componentdendrite
A0030496cellular_componentmidbody
A0030742molecular_functionGTP-dependent protein binding
A0031252cellular_componentcell leading edge
A0031256cellular_componentleading edge membrane
A0031274biological_processpositive regulation of pseudopodium assembly
A0031333biological_processnegative regulation of protein-containing complex assembly
A0031996molecular_functionthioesterase binding
A0032427molecular_functionGBD domain binding
A0032467biological_processpositive regulation of cytokinesis
A0032956biological_processregulation of actin cytoskeleton organization
A0032991cellular_componentprotein-containing complex
A0034191molecular_functionapolipoprotein A-I receptor binding
A0034329biological_processcell junction assembly
A0035050biological_processembryonic heart tube development
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0038189biological_processneuropilin signaling pathway
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0044788biological_processhost-mediated perturbation of viral process
A0045177cellular_componentapical part of cell
A0045198biological_processestablishment of epithelial cell apical/basal polarity
A0045335cellular_componentphagocytic vesicle
A0048549biological_processpositive regulation of pinocytosis
A0051130biological_processpositive regulation of cellular component organization
A0051233cellular_componentspindle midzone
A0051489biological_processregulation of filopodium assembly
A0051491biological_processpositive regulation of filopodium assembly
A0051492biological_processregulation of stress fiber assembly
A0051496biological_processpositive regulation of stress fiber assembly
A0051683biological_processestablishment of Golgi localization
A0051988biological_processregulation of attachment of spindle microtubules to kinetochore
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
A0060997biological_processdendritic spine morphogenesis
A0061630molecular_functionubiquitin protein ligase activity
A0070062cellular_componentextracellular exosome
A0071944cellular_componentcell periphery
A0072384biological_processorganelle transport along microtubule
A0072686cellular_componentmitotic spindle
A0086100biological_processendothelin receptor signaling pathway
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099175biological_processregulation of postsynapse organization
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000322cellular_componentstorage vacuole
B0003015biological_processheart process
B0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0005925cellular_componentfocal adhesion
B0006897biological_processendocytosis
B0006911biological_processphagocytosis, engulfment
B0007015biological_processactin filament organization
B0007030biological_processGolgi organization
B0007163biological_processestablishment or maintenance of cell polarity
B0007165biological_processsignal transduction
B0007229biological_processintegrin-mediated signaling pathway
B0007264biological_processsmall GTPase-mediated signal transduction
B0007399biological_processnervous system development
B0009653biological_processanatomical structure morphogenesis
B0010591biological_processregulation of lamellipodium assembly
B0010592biological_processpositive regulation of lamellipodium assembly
B0015630cellular_componentmicrotubule cytoskeleton
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0017119cellular_componentGolgi transport complex
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0030010biological_processestablishment of cell polarity
B0030036biological_processactin cytoskeleton organization
B0030154biological_processcell differentiation
B0030175cellular_componentfilopodium
B0030225biological_processmacrophage differentiation
B0030307biological_processpositive regulation of cell growth
B0030335biological_processpositive regulation of cell migration
B0030425cellular_componentdendrite
B0030496cellular_componentmidbody
B0030742molecular_functionGTP-dependent protein binding
B0031252cellular_componentcell leading edge
B0031256cellular_componentleading edge membrane
B0031274biological_processpositive regulation of pseudopodium assembly
B0031333biological_processnegative regulation of protein-containing complex assembly
B0031996molecular_functionthioesterase binding
B0032427molecular_functionGBD domain binding
B0032467biological_processpositive regulation of cytokinesis
B0032956biological_processregulation of actin cytoskeleton organization
B0032991cellular_componentprotein-containing complex
B0034191molecular_functionapolipoprotein A-I receptor binding
B0034329biological_processcell junction assembly
B0035050biological_processembryonic heart tube development
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0038189biological_processneuropilin signaling pathway
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0044788biological_processhost-mediated perturbation of viral process
B0045177cellular_componentapical part of cell
B0045198biological_processestablishment of epithelial cell apical/basal polarity
B0045335cellular_componentphagocytic vesicle
B0048549biological_processpositive regulation of pinocytosis
B0051130biological_processpositive regulation of cellular component organization
B0051233cellular_componentspindle midzone
B0051489biological_processregulation of filopodium assembly
B0051491biological_processpositive regulation of filopodium assembly
B0051492biological_processregulation of stress fiber assembly
B0051496biological_processpositive regulation of stress fiber assembly
B0051683biological_processestablishment of Golgi localization
B0051988biological_processregulation of attachment of spindle microtubules to kinetochore
B0060071biological_processWnt signaling pathway, planar cell polarity pathway
B0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
B0060997biological_processdendritic spine morphogenesis
B0061630molecular_functionubiquitin protein ligase activity
B0070062cellular_componentextracellular exosome
B0071944cellular_componentcell periphery
B0072384biological_processorganelle transport along microtubule
B0072686cellular_componentmitotic spindle
B0086100biological_processendothelin receptor signaling pathway
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099175biological_processregulation of postsynapse organization
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C0000139cellular_componentGolgi membrane
C0000166molecular_functionnucleotide binding
C0000322cellular_componentstorage vacuole
C0003015biological_processheart process
C0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005911cellular_componentcell-cell junction
C0005925cellular_componentfocal adhesion
C0006897biological_processendocytosis
C0006911biological_processphagocytosis, engulfment
C0007015biological_processactin filament organization
C0007030biological_processGolgi organization
C0007163biological_processestablishment or maintenance of cell polarity
C0007165biological_processsignal transduction
C0007229biological_processintegrin-mediated signaling pathway
C0007264biological_processsmall GTPase-mediated signal transduction
C0007399biological_processnervous system development
C0009653biological_processanatomical structure morphogenesis
C0010591biological_processregulation of lamellipodium assembly
C0010592biological_processpositive regulation of lamellipodium assembly
C0015630cellular_componentmicrotubule cytoskeleton
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0017119cellular_componentGolgi transport complex
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0030010biological_processestablishment of cell polarity
C0030036biological_processactin cytoskeleton organization
C0030154biological_processcell differentiation
C0030175cellular_componentfilopodium
C0030225biological_processmacrophage differentiation
C0030307biological_processpositive regulation of cell growth
C0030335biological_processpositive regulation of cell migration
C0030425cellular_componentdendrite
C0030496cellular_componentmidbody
C0030742molecular_functionGTP-dependent protein binding
C0031252cellular_componentcell leading edge
C0031256cellular_componentleading edge membrane
C0031274biological_processpositive regulation of pseudopodium assembly
C0031333biological_processnegative regulation of protein-containing complex assembly
C0031996molecular_functionthioesterase binding
C0032427molecular_functionGBD domain binding
C0032467biological_processpositive regulation of cytokinesis
C0032956biological_processregulation of actin cytoskeleton organization
C0032991cellular_componentprotein-containing complex
C0034191molecular_functionapolipoprotein A-I receptor binding
C0034329biological_processcell junction assembly
C0035050biological_processembryonic heart tube development
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0038189biological_processneuropilin signaling pathway
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0044788biological_processhost-mediated perturbation of viral process
C0045177cellular_componentapical part of cell
C0045198biological_processestablishment of epithelial cell apical/basal polarity
C0045335cellular_componentphagocytic vesicle
C0048549biological_processpositive regulation of pinocytosis
C0051130biological_processpositive regulation of cellular component organization
C0051233cellular_componentspindle midzone
C0051489biological_processregulation of filopodium assembly
C0051491biological_processpositive regulation of filopodium assembly
C0051492biological_processregulation of stress fiber assembly
C0051496biological_processpositive regulation of stress fiber assembly
C0051683biological_processestablishment of Golgi localization
C0051988biological_processregulation of attachment of spindle microtubules to kinetochore
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
C0060997biological_processdendritic spine morphogenesis
C0061630molecular_functionubiquitin protein ligase activity
C0070062cellular_componentextracellular exosome
C0071944cellular_componentcell periphery
C0072384biological_processorganelle transport along microtubule
C0072686cellular_componentmitotic spindle
C0086100biological_processendothelin receptor signaling pathway
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099175biological_processregulation of postsynapse organization
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
D0000139cellular_componentGolgi membrane
D0000166molecular_functionnucleotide binding
D0000322cellular_componentstorage vacuole
D0003015biological_processheart process
D0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005789cellular_componentendoplasmic reticulum membrane
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005911cellular_componentcell-cell junction
D0005925cellular_componentfocal adhesion
D0006897biological_processendocytosis
D0006911biological_processphagocytosis, engulfment
D0007015biological_processactin filament organization
D0007030biological_processGolgi organization
D0007163biological_processestablishment or maintenance of cell polarity
D0007165biological_processsignal transduction
D0007229biological_processintegrin-mediated signaling pathway
D0007264biological_processsmall GTPase-mediated signal transduction
D0007399biological_processnervous system development
D0009653biological_processanatomical structure morphogenesis
D0010591biological_processregulation of lamellipodium assembly
D0010592biological_processpositive regulation of lamellipodium assembly
D0015630cellular_componentmicrotubule cytoskeleton
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0017119cellular_componentGolgi transport complex
D0019901molecular_functionprotein kinase binding
D0021762biological_processsubstantia nigra development
D0030010biological_processestablishment of cell polarity
D0030036biological_processactin cytoskeleton organization
D0030154biological_processcell differentiation
D0030175cellular_componentfilopodium
D0030225biological_processmacrophage differentiation
D0030307biological_processpositive regulation of cell growth
D0030335biological_processpositive regulation of cell migration
D0030425cellular_componentdendrite
D0030496cellular_componentmidbody
D0030742molecular_functionGTP-dependent protein binding
D0031252cellular_componentcell leading edge
D0031256cellular_componentleading edge membrane
D0031274biological_processpositive regulation of pseudopodium assembly
D0031333biological_processnegative regulation of protein-containing complex assembly
D0031996molecular_functionthioesterase binding
D0032427molecular_functionGBD domain binding
D0032467biological_processpositive regulation of cytokinesis
D0032956biological_processregulation of actin cytoskeleton organization
D0032991cellular_componentprotein-containing complex
D0034191molecular_functionapolipoprotein A-I receptor binding
D0034329biological_processcell junction assembly
D0035050biological_processembryonic heart tube development
D0036464cellular_componentcytoplasmic ribonucleoprotein granule
D0038189biological_processneuropilin signaling pathway
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0044788biological_processhost-mediated perturbation of viral process
D0045177cellular_componentapical part of cell
D0045198biological_processestablishment of epithelial cell apical/basal polarity
D0045335cellular_componentphagocytic vesicle
D0048549biological_processpositive regulation of pinocytosis
D0051130biological_processpositive regulation of cellular component organization
D0051233cellular_componentspindle midzone
D0051489biological_processregulation of filopodium assembly
D0051491biological_processpositive regulation of filopodium assembly
D0051492biological_processregulation of stress fiber assembly
D0051496biological_processpositive regulation of stress fiber assembly
D0051683biological_processestablishment of Golgi localization
D0051988biological_processregulation of attachment of spindle microtubules to kinetochore
D0060071biological_processWnt signaling pathway, planar cell polarity pathway
D0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
D0060997biological_processdendritic spine morphogenesis
D0061630molecular_functionubiquitin protein ligase activity
D0070062cellular_componentextracellular exosome
D0071944cellular_componentcell periphery
D0072384biological_processorganelle transport along microtubule
D0072686cellular_componentmitotic spindle
D0086100biological_processendothelin receptor signaling pathway
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099175biological_processregulation of postsynapse organization
D1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
E0043087biological_processregulation of GTPase activity
F0043087biological_processregulation of GTPase activity
Functional Information from PDB Data
site_idAC1
Number of Residues23
Detailsbinding site for residue GTP A 201
ChainResidue
AGLY12
ATHR35
AGLY60
AGLN116
AASP118
ALEU119
AALA159
ALEU160
AMG202
AHOH301
AHOH307
AALA13
EASN928
EARG930
EGLU931
ETYR1197
AVAL14
AGLY15
ALYS16
ATHR17
ACYS18
ATYR32
APRO34

site_idAC2
Number of Residues6
Detailsbinding site for residue MG A 202
ChainResidue
ATHR17
ATHR35
AASP57
ATHR58
AGTP201
AHOH301

site_idAC3
Number of Residues23
Detailsbinding site for residue GTP B 201
ChainResidue
BGLY12
BALA13
BVAL14
BGLY15
BLYS16
BTHR17
BCYS18
BTYR32
BPRO34
BTHR35
BGLY60
BGLN116
BASP118
BLEU119
BALA159
BLEU160
BMG202
BHOH301
BHOH308
FASN928
FARG930
FGLU931
FTYR1197

site_idAC4
Number of Residues6
Detailsbinding site for residue MG B 202
ChainResidue
BTHR17
BTHR35
BASP57
BTHR58
BGTP201
BHOH301

site_idAC5
Number of Residues23
Detailsbinding site for residue GTP C 201
ChainResidue
CGLY12
CALA13
CVAL14
CGLY15
CLYS16
CTHR17
CCYS18
CPHE28
CTYR32
CPRO34
CTHR35
CGLY60
CGLN116
CASP118
CLEU119
CSER158
CALA159
CLEU160
CMG202
CHOH301
CHOH302
CHOH307
EGLN955

site_idAC6
Number of Residues6
Detailsbinding site for residue MG C 202
ChainResidue
CTHR17
CTHR35
CASP57
CTHR58
CGTP201
CHOH302

site_idAC7
Number of Residues20
Detailsbinding site for residue GTP D 201
ChainResidue
DGLN116
DASP118
DLEU119
DALA159
DLEU160
DMG202
DHOH303
FGLN955
DGLY12
DALA13
DVAL14
DGLY15
DLYS16
DTHR17
DCYS18
DPHE28
DTYR32
DPRO34
DTHR35
DGLY60

site_idAC8
Number of Residues5
Detailsbinding site for residue MG D 202
ChainResidue
DTHR17
DTHR35
DASP57
DTHR58
DGTP201

Functional Information from PROSITE/UniProt
site_idPS00509
Number of Residues15
DetailsRAS_GTPASE_ACTIV_1 Ras GTPase-activating proteins (rasGAP) domain signature. NlLYYRYMNPAIVAP
ChainResidueDetails
EASN1102-PRO1116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues32
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues40
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues16
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsModified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20622875","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"14506284","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues4
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues4
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues498
DetailsDomain: {"description":"Ras-GAP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00167","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q3UQ44","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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