5CIR
Crystal structure of death receptor 4 (DR4; TNFFRSF10A) bound to TRAIL (TNFSF10)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, D) | Tumor necrosis factor ligand superfamily member 10 | polymer | 169 | 19652.0 | 3 | UniProt (P50591) Pfam (PF00229) | Homo sapiens (Human) | Apo-2 ligand,Apo-2L,TNF-related apoptosis-inducing ligand,Protein TRAIL |
| 2 | D, E, F (E, F, G) | Tumor necrosis factor receptor superfamily member 10A | polymer | 108 | 11749.3 | 3 | UniProt (O00220) Pfam (PF00020) | Homo sapiens (Human) | Death receptor 4,TNF-related apoptosis-inducing ligand receptor 1,TRAIL-R1 |
| 3 | G (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | H (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | I, J, K, L (B, D, E, F) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, B, D: 114 - 281 (UniProt: P50591)
E, F, G: 125 - 232 (UniProt: O00220)
| PDB | External Database | Details |
|---|---|---|
| Met 113 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Arg 141 | His 141 | variant |
| Thr 209 | Arg 209 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 94204.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 100.9 | |
| All* | Total formula weight | 94304.9 |
