5CI7
Structure of ULK1 bound to a selective inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase ULK1 | polymer | 287 | 32320.3 | 1 | UniProt (O75385) Pfam (PF00069) | Homo sapiens (Human) | Autophagy-related protein 1 homolog,hATG1,Unc-51-like kinase 1 |
| 2 | B (A) | N-[3-({4-[(3-aminopropyl)amino]-5-iodopyrimidin-2-yl}amino)phenyl]pyrrolidine-1-carboxamide | non-polymer | 481.3 | 1 | Chemie (51W) | |||
| 3 | C, D, E (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | F (A) | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
A: 1 - 283 (UniProt: O75385)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 37 | Glu 37 | engineered mutation |
| Ala 38 | Lys 38 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32320.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 757.6 | |
| All* | Total formula weight | 33077.9 |
