5CEI
Crystal structure of CDK8:Cyclin C complex with compound 22
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 8 | polymer | 406 | 47105.9 | 1 | UniProt (P49336) Pfam (PF00069) | Homo sapiens (Human) | Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35 |
| 2 | B (B) | Cyclin-C | polymer | 287 | 33710.1 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) | Homo sapiens (Human) | SRB11 homolog,hSRB11 |
| 3 | C, D, E, F, K... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 4 | G, H, I, N, O... (A, B) | FORMIC ACID | non-polymer | 46.0 | 7 | Chemie (FMT) | |||
| 5 | J (A) | 4-(4-iodophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide | non-polymer | 410.2 | 1 | Chemie (50R) | |||
| 6 | S, T (A, B) | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
A: 1 - 403 (UniProt: P49336)
B: 1 - 283 (UniProt: P24863)
| PDB | External Database | Details |
|---|---|---|
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80816.0 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1228.9 | |
| All* | Total formula weight | 82045.0 |
