Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0016538 | molecular_function | cyclin-dependent protein serine/threonine kinase regulator activity |
| B | 0016592 | cellular_component | mediator complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045023 | biological_process | G0 to G1 transition |
| B | 0045746 | biological_process | negative regulation of Notch signaling pathway |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 1990508 | cellular_component | CKM complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 501 |
| Chain | Residue |
| A | ARG71 |
| A | GLU72 |
| B | SER9 |
| B | GLN13 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 502 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | GLU23 |
| A | LYS41 |
| A | GLU17 |
| A | PHE20 |
| A | GLU21 |
| A | TYR22 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | LYS301 |
| A | VAL302 |
| A | LYS303 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 505 |
| Chain | Residue |
| A | LYS52 |
| A | GLU66 |
| A | ALA172 |
| A | ASP173 |
| A | 50R508 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue FMT A 506 |
| Chain | Residue |
| A | GLU165 |
| A | ARG166 |
| A | ARG168 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue FMT A 507 |
| Chain | Residue |
| A | ARG168 |
| A | SER343 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residue 50R A 508 |
| Chain | Residue |
| A | VAL27 |
| A | TYR32 |
| A | VAL35 |
| A | ALA50 |
| A | LYS52 |
| A | ILE79 |
| A | TYR99 |
| A | ALA100 |
| A | ASP103 |
| A | ALA155 |
| A | LEU158 |
| A | ASP173 |
| A | ARG356 |
| A | FMT505 |
| A | HOH668 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 509 |
| Chain | Residue |
| A | ASP305 |
| A | HIS310 |
| B | LYS242 |
| B | ASN243 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 301 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 302 |
| Chain | Residue |
| B | GLU35 |
| B | GLU239 |
| B | GLN240 |
| B | ASN243 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 303 |
| Chain | Residue |
| B | ALA0 |
| B | ALA2 |
| B | VAL152 |
| B | ARG157 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 304 |
| Chain | Residue |
| B | PHE31 |
| B | SER255 |
| B | LYS256 |
| B | MET257 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue FMT B 305 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue FMT B 306 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 307 |
| Chain | Residue |
| B | ILE42 |
| B | ASN46 |
| B | TRP241 |
| B | PHE244 |
| B | GLU246 |
| B | HOH401 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 26 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGTYGHVYkAkrkdgkddkd........YALK |
| Chain | Residue | Details |
| A | VAL27-LYS52 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNILV |
| Chain | Residue | Details |
| A | VAL147-VAL159 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Region: {"description":"Interaction with CCNC"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 98 |
| Details | Domain: {"description":"Cyclin N-terminal"} |
