5CEH
Structure of histone lysine demethylase KDM5A in complex with selective inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific demethylase 5A | polymer | 790 | 90703.9 | 1 | UniProt (P29375) Pfam (PF02375) Pfam (PF01388) Pfam (PF00628) Pfam (PF02373) Pfam (PF21323) Pfam (PF02928) | Homo sapiens (Human) | Histone demethylase JARID1A,Jumonji/ARID domain-containing protein 1A,Retinoblastoma-binding protein 2,RBBP-2 |
| 2 | B (B) | Unknown Peptide | polymer | 10 | 869.1 | 1 | Homo sapiens (Human) | ||
| 3 | C (A) | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
| 4 | D, E (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | F (A) | 7-oxo-5-phenyl-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile | non-polymer | 278.3 | 1 | Chemie (50P) | |||
| 6 | G (A) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A: 12 - 797 (UniProt: P29375)
| PDB | External Database | Details |
|---|---|---|
| Ser 11 | - | expression tag |
| Gly 798 | - | expression tag |
| Asn 799 | - | expression tag |
| Ser 800 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 91573.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 467.8 | |
| All* | Total formula weight | 92040.8 |
