5CEH

Structure of histone lysine demethylase KDM5A in complex with selective inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue NI A 901

Chain	Residue
A	HIS483
A	GLU485
A	HIS571
A	50P904
A	HOH1001

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 902

Chain	Residue
A	CYS676
A	CYS679
A	CYS699
A	HIS702

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site_id	AC3
Number of Residues	5
Details	binding site for residue ZN A 903

Chain	Residue
A	CYS690
A	SER691
A	CYS692
A	CYS707
A	CYS709

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site_id	AC4
Number of Residues	14
Details	binding site for residue 50P A 904

Chain	Residue
A	TYR409
A	GLY410
A	ALA411
A	TYR472
A	VAL473
A	SER479
A	PHE480
A	HIS483
A	ASN493
A	LYS501
A	HIS571
A	ASN575
A	NI901
A	HOH1001

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Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	45
Details	ZF_PHD_1 Zinc finger PHD-type signature. CmfCgrgnnedkl....................................LlCdg..Cdds.YHtfClipplpdvpkgd.................................WrCpkC

Chain	Residue	Details
A	CYS296-CYS340

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	ZN_FING: PHD-type 1 => ECO:0000255|PROSITE-ProRule:PRU00146

Chain	Residue	Details
A	LEU293-GLU343

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site_id	SWS_FT_FI2
Number of Residues	52
Details	ZN_FING: C5HC2 => ECO:0000269|PubMed:27214401, ECO:0000269|PubMed:27499454, ECO:0007744|PDB:5CEH

Chain	Residue	Details
A	CYS676-LEU728

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:27427228

Chain	Residue	Details
A	TYR409
A	SER491
A	ASN493
A	LYS501

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26645689, ECO:0000305|PubMed:27214401, ECO:0000305|PubMed:27427228, ECO:0000305|PubMed:27499454

Chain	Residue	Details
A	HIS483
A	HIS571

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:26645689, ECO:0000305|PubMed:27214401, ECO:0000305|PubMed:27427228, ECO:0000305|PubMed:27499454

Chain	Residue	Details
A	GLU485

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER204

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS191

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