5CEH
Structure of histone lysine demethylase KDM5A in complex with selective inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue NI A 901 |
| Chain | Residue |
| A | HIS483 |
| A | GLU485 |
| A | HIS571 |
| A | 50P904 |
| A | HOH1001 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 902 |
| Chain | Residue |
| A | CYS676 |
| A | CYS679 |
| A | CYS699 |
| A | HIS702 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 903 |
| Chain | Residue |
| A | CYS690 |
| A | SER691 |
| A | CYS692 |
| A | CYS707 |
| A | CYS709 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue 50P A 904 |
| Chain | Residue |
| A | TYR409 |
| A | GLY410 |
| A | ALA411 |
| A | TYR472 |
| A | VAL473 |
| A | SER479 |
| A | PHE480 |
| A | HIS483 |
| A | ASN493 |
| A | LYS501 |
| A | HIS571 |
| A | ASN575 |
| A | NI901 |
| A | HOH1001 |
Functional Information from PROSITE/UniProt
| site_id | PS01359 |
| Number of Residues | 45 |
| Details | ZF_PHD_1 Zinc finger PHD-type signature. CmfCgrgnnedkl....................................LlCdg..Cdds.YHtfClipplpdvpkgd.................................WrCpkC |
| Chain | Residue | Details |
| A | CYS296-CYS340 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 41 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 90 |
| Details | Domain: {"description":"ARID","evidences":[{"source":"PROSITE-ProRule","id":"PRU00355","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 166 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 52 |
| Details | Zinc finger: {"description":"C5HC2","evidences":[{"source":"PubMed","id":"27214401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27499454","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5CEH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Motif: {"description":"GSGFP motif","evidences":[{"source":"UniProtKB","id":"Q3UXZ9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214401","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27499454","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214401","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27499454","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
