5C27
Crystal structure of SYK in complex with compound 2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein kinase SYK | polymer | 299 | 35040.9 | 1 | UniProt (P43405) Pfam (PF07714) In PDB | Homo sapiens (Human) | Spleen tyrosine kinase,p72-Syk |
2 | D | GLU-VAL-TYR-GLU-SER | polymer | 5 | 625.6 | 1 | Homo sapiens (Human) | ||
3 | A | 3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}-N-[4-(methylcarbamoyl)phenyl]benzamide | non-polymer | 522.6 | 1 | Chemie (50J) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | water | water | 18.0 | 198 | Chemie (HOH) |
Sequence modifications
A: 343 - 635 (UniProt: P43405)
PDB | External Database | Details |
---|---|---|
His 636 | - | expression tag |
His 637 | - | expression tag |
His 638 | - | expression tag |
His 639 | - | expression tag |
His 640 | - | expression tag |
His 641 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 35666.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 614.6 | |
All* | Total formula weight | 36281.2 |