5C0S
Crystal structure of a generation 4 influenza hemagglutinin stabilized stem in complex with the broadly neutralizing antibody CR6261
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hemagglutinin, Envelope glycoprotein, Fibritin fusion protein | polymer | 305 | 34211.7 | 1 | UniProt (Q6WG00) UniProt (P04578) UniProt (D9IEJ2) Pfam (PF00509) | Influenza A virus Human immunodeficiency virus type 1 group M subtype B Enterobacteria phage T4 | Env polyprotein,Env polyprotein |
| 2 | B (H) | CR6261 antibody heavy chain | polymer | 226 | 23981.1 | 1 | Homo sapiens (Human) | ||
| 3 | C (L) | CR6261 antibody light chain | polymer | 221 | 23257.8 | 1 | Homo sapiens (Human) |
Sequence modifications
A: 1 - 32 (UniProt: Q6WG00)
A: 36 - 107 (UniProt: Q6WG00)
A: 110 - 136 (UniProt: P04578)
A: 143 - 174 (UniProt: P04578)
A: 175 - 256 (UniProt: Q6WG00)
A: 260 - 287 (UniProt: D9IEJ2)
A: 36 - 107 (UniProt: Q6WG00)
| PDB | External Database | Details |
|---|---|---|
| Gly 33 | - | linker |
| Ser 34 | - | linker |
| Gly 35 | - | linker |
| Gln 47 | Ser 339 | conflict |
| Arg 47 | Ile 340 | conflict |
| Glu 47 | Gln 341 | conflict |
| Thr 47 | Ser 342 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asp 110 | Trp 628 | conflict |
| Pro 111 | Met 629 | conflict |
| Ile 123 | Leu 641 | conflict |
| Tyr 125 | His 643 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asn 137 | - | linker |
| Gly 138 | - | linker |
| Thr 139 | - | linker |
| Gly 140 | - | linker |
| Gly 141 | - | linker |
| Gly 142 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 108 | - | linker |
| Gly 109 | - | linker |
| Pro 257 | - | linker |
| Gly 258 | - | linker |
| Ser 259 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 288 | - | expression tag |
| Arg 289 | - | expression tag |
| Leu 290 | - | expression tag |
| Val 291 | - | expression tag |
| Pro 292 | - | expression tag |
| Arg 293 | - | expression tag |
| Gly 294 | - | expression tag |
| Ser 295 | - | expression tag |
| Gly 296 | - | expression tag |
| His 297 | - | expression tag |
| His 298 | - | expression tag |
| His 299 | - | expression tag |
| His 300 | - | expression tag |
| His 301 | - | expression tag |
| His 302 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 81450.7 | |
| All* | Total formula weight | 81450.7 |
