5BWX
X-RAY CRYSTAL STRUCTURE AT 1.70A RESOLUTION OF HUMAN MITOCHONDRIAL BRANCHED CHAIN AMINOTRANSFERASE (BCATM) COMPLEXED WITH A 4-CHLORO-2-FLUORO SUBSTITUTED PYRAZOLOPYRIMIDINONE COMPOUND AND AN INTERNAL ALDIMINE LINKED PLP COFACTOR.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Branched-chain-amino-acid aminotransferase, mitochondrial | polymer | 369 | 41725.4 | 2 | UniProt (O15382) Pfam (PF01063) In PDB | Homo sapiens (Human) | BCAT(m),Placental protein 18,PP18 |
| 2 | A, B | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 2 | Chemie (PLP) | |||
| 3 | A, B | 5-butyl-2-[(4-chloro-2-fluorobenzyl)amino]-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile | non-polymer | 373.8 | 2 | Chemie (4W4) | |||
| 4 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 17 | Chemie (EDO) | |||
| 5 | B, A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | B, A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 8 | water | water | 18.0 | 919 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 365 (UniProt: O15382)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83450.8 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 2630.3 | |
| All* | Total formula weight | 86081.1 |
