5BTR

Crystal structure of SIRT1 in complex with resveratrol and an AMC-containing peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	NAD-dependent protein deacetylase sirtuin-1	polymer	397	45040.4	3	UniProt (Q96EB6) Pfam (PF02146) In PDB	Homo sapiens (Human)	hSIRT1,Regulatory protein SIR2 homolog 1,SIR2-like protein 1,hSIR2
2	D, E, F	AMC-containing peptide	polymer	5	796.0	3		synthetic
3	A, B, C	ZINC ION	non-polymer		65.4	3	Chemie (ZN)
4	A, B, C, D, E...	RESVERATROL	non-polymer		228.2	9	Chemie (STL)
5		water	water		18.0	11	Chemie (HOH)

Sequence modifications

A, B, C: 143 - 512 (UniProt: Q96EB6)

PDB	External Database	Details
Gly 141	-	expression tag
Ser 142	-	expression tag
Ser 253	Cys 253	engineered mutation
Ser 268	Cys 268	engineered mutation
Ser 501	Cys 501	engineered mutation
Ser 502	Cys 502	engineered mutation

A, B, C: 641 - 665 (UniProt: Q96EB6)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	137509.0
Non-Polymers*	Number of molecules	12
	Total formula weight	2250.4
All*	Total formula weight	139759.4

*Water molecules are not included.