5BTR
Crystal structure of SIRT1 in complex with resveratrol and an AMC-containing peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | NAD-dependent protein deacetylase sirtuin-1 | polymer | 397 | 45040.4 | 3 | UniProt (Q96EB6) Pfam (PF02146) | Homo sapiens (Human) | hSIRT1,Regulatory protein SIR2 homolog 1,SIR2-like protein 1,hSIR2 |
| 2 | D, E, F (D, E, F) | AMC-containing peptide | polymer | 5 | 796.0 | 3 | synthetic | ||
| 3 | G, I, L (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | H, J, K, M, N... (A, B, C, D, E...) | RESVERATROL | non-polymer | 228.2 | 9 | Chemie (STL) | |||
| 5 | S, T, U (A, B, E) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A, B, C: 143 - 512 (UniProt: Q96EB6)
A, B, C: 641 - 665 (UniProt: Q96EB6)
| PDB | External Database | Details |
|---|---|---|
| Gly 141 | - | expression tag |
| Ser 142 | - | expression tag |
| Ser 253 | Cys 253 | engineered mutation |
| Ser 268 | Cys 268 | engineered mutation |
| Ser 501 | Cys 501 | engineered mutation |
| Ser 502 | Cys 502 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 137509.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2250.4 | |
| All* | Total formula weight | 139759.4 |
