Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5BTR

Crystal structure of SIRT1 in complex with resveratrol and an AMC-containing peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0070403	molecular_function	NAD+ binding
B	0070403	molecular_function	NAD+ binding
C	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 701

Chain	Residue
A	CYS371
A	CYS374
A	CYS395
A	CYS398

site_id	AC2
Number of Residues	10
Details	binding site for residue STL A 702

Chain	Residue
A	ASP298
A	PHE414
A	LYS444
D	FDL4
D	STL102
A	THR209
A	PRO212
A	ASP292
A	GLN294
A	ALA295

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN B 701

Chain	Residue
B	CYS371
B	CYS374
B	CYS395
B	CYS398

site_id	AC4
Number of Residues	9
Details	binding site for residue STL B 702

Chain	Residue
B	ARG274
B	ASP292
B	GLN294
B	ALA295
B	ASP298
B	PHE414
B	LYS444
B	STL703
E	FDL4

site_id	AC5
Number of Residues	11
Details	binding site for residue STL B 703

Chain	Residue
B	PRO212
B	LEU215
B	GLN222
B	ASN226
B	ASP298
B	PHE414
B	GLY415
B	STL702
E	ARG1
E	LYS3
E	FDL4

site_id	AC6
Number of Residues	5
Details	binding site for residue ZN C 701

Chain	Residue
C	CYS371
C	ILE373
C	CYS374
C	CYS395
C	ALA405

site_id	AC7
Number of Residues	7
Details	binding site for residue STL C 702

Chain	Residue
C	PRO212
C	ASP292
C	GLN294
C	ASP298
C	LYS444
C	STL703
F	FDL4

site_id	AC8
Number of Residues	12
Details	binding site for residue STL C 703

Chain	Residue
C	PRO212
C	LEU215
C	THR219
C	GLN222
C	ILE223
C	ASN226
C	PHE414
C	GLY415
C	STL702
F	ARG1
F	LYS3
F	FDL4

site_id	AC9
Number of Residues	11
Details	binding site for residue STL D 101

Chain	Residue
A	LEU206
A	PRO211
A	ILE223
A	ASN226
A	GLU230
A	ARG446
A	PRO447
A	LEU450
D	HIS2
D	LYS3
D	FDL4

site_id	AD1
Number of Residues	11
Details	binding site for residue STL D 102

Chain	Residue
A	LEU215
A	GLN222
A	ASN226
A	ASP298
A	GLU300
A	PHE414
A	GLY415
A	STL702
D	ARG1
D	LYS3
D	FDL4

site_id	AD2
Number of Residues	9
Details	binding site for residue STL E 101

Chain	Residue
B	LEU206
B	PRO211
B	ILE223
B	ASN226
B	GLU230
B	PRO447
E	HIS2
E	LYS3
E	FDL4

site_id	AD3
Number of Residues	11
Details	binding site for residue STL F 101

Chain	Residue
C	PRO447
C	LEU450
F	HIS2
F	LYS3
F	FDL4
C	LEU206
C	PRO211
C	ILE223
C	ASN226
C	GLU230
C	ARG446

site_id	AD4
Number of Residues	7
Details	binding site for Di-peptide ACE D 0 and ARG D 1

Chain	Residue
A	ASN226
C	PHE148
C	ASP150
C	PRO180
D	HIS2
D	LYS3
D	STL102

site_id	AD5
Number of Residues	18
Details	binding site for Di-peptide LYS D 3 and FDL D 4

Chain	Residue
A	LEU206
A	THR209
A	ARG274
A	PHE297
A	HIS363
A	VAL412
A	PHE414
A	GLY415
A	GLU416
A	ASN417
A	LEU418
A	ARG446
A	STL702
D	ACE0
D	ARG1
D	HIS2
D	STL101
D	STL102

site_id	AD6
Number of Residues	7
Details	binding site for Di-peptide ACE E 0 and ARG E 1

Chain	Residue
A	PHE148
A	ASP150
A	PRO180
B	ASN226
B	STL703
E	HIS2
E	LYS3

site_id	AD7
Number of Residues	15
Details	binding site for Di-peptide LYS E 3 and FDL E 4

Chain	Residue
B	LEU206
B	HIS363
B	VAL412
B	PHE414
B	GLY415
B	GLU416
B	ASN417
B	LEU418
B	ARG446
B	STL702
B	STL703
E	ACE0
E	ARG1
E	HIS2
E	STL101

site_id	AD8
Number of Residues	7
Details	binding site for Di-peptide ACE F 0 and ARG F 1

Chain	Residue
B	ASP150
B	PRO180
C	TYR185
C	ASN226
C	STL703
F	HIS2
F	LYS3

site_id	AD9
Number of Residues	19
Details	binding site for Di-peptide LYS F 3 and FDL F 4

Chain	Residue
C	LEU206
C	THR209
C	PHE297
C	HIS363
C	VAL412
C	PHE413
C	PHE414
C	GLY415
C	GLU416
C	ASN417
C	LYS444
C	ARG446
C	PRO447
C	STL702
C	STL703
F	ACE0
F	ARG1
F	HIS2
F	STL101

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	520
Details	Domain: {"description":"Deacetylase sirtuin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	9
Details	Region: {"description":"Required for interaction with the sumoylated form of CCAR2","evidences":[{"source":"PubMed","id":"25406032","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	21
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	18
Details	Motif: {"description":"Nuclear export signal","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11672523","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12006491","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12535671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17290224","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004385","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18235501","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18485871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19934257","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28497810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38512451","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	59
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8IXJ6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	11
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q923E4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	5
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"Q923E4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)