5BT5
Crystal structure of BRD2 second bromodomain in complex with SGC-CBP30 chemical probe
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 2 | polymer | 114 | 13375.4 | 1 | UniProt (P25440) Pfam (PF00439) | Homo sapiens (Human) | O27.1.1,Really interesting new gene 3 protein, BRD2 |
| 2 | B, C, D, E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 3 | F (A) | 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole | non-polymer | 509.0 | 1 | Chemie (2LO) | |||
| 4 | G (A) | water | water | 18.0 | 127 | Chemie (HOH) |
Sequence modifications
A: 344 - 455 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Ser 342 | - | expression tag |
| Met 343 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13375.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 757.3 | |
| All* | Total formula weight | 14132.7 |
