5BT4
Crystal structure of BRD4 first bromodomain in complex with SGC-CBP30 chemical probe
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 3 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (Human) | Protein HUNK1, BRD4 |
| 2 | D, F, H (A, B, C) | 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole | non-polymer | 509.0 | 3 | Chemie (2LO) | |||
| 3 | E, G (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | I, J, K (A, B, C) | water | water | 18.0 | 346 | Chemie (HOH) |
Sequence modifications
A, B, C: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
| Met 2 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 45298.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1651.3 | |
| All* | Total formula weight | 46949.4 |
