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5BT4

Crystal structure of BRD4 first bromodomain in complex with SGC-CBP30 chemical probe

Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue 2LO A 201
ChainResidue
ATRP81
CGLN127
CASP128
APRO82
ALEU92
ALEU94
AASN140
AHOH305
AHOH321
CASN121
CGLU124

site_idAC2
Number of Residues6
Detailsbinding site for residue EDO A 202
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135
AHOH320

site_idAC3
Number of Residues12
Detailsbinding site for residue 2LO B 201
ChainResidue
BTRP81
BGLN84
CPRO82
CPHE83
CLYS91
CLEU92
CLEU94
CASN140
CILE146
C2LO201
CHOH302
CHOH343

site_idAC4
Number of Residues4
Detailsbinding site for residue EDO B 202
ChainResidue
BASP145
BHOH378
BHOH419
CLYS76

site_idAC5
Number of Residues15
Detailsbinding site for residue 2LO C 201
ChainResidue
BPRO82
BPHE83
BLEU92
BASN140
BILE146
B2LO201
BHOH304
BHOH306
CGLN78
CTRP81
CPRO82
CGLN84
CGLN85
CMET149
CHOH315

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140
BASN140
CASN140

site_idSWS_FT_FI2
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99
BLYS99
CLYS99

226707

PDB entries from 2024-10-30

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