5BT3
Crystal structure of EP300 bromodomain in complex with SGC-CBP30 chemical probe
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone acetyltransferase p300 | polymer | 116 | 13826.8 | 1 | UniProt (Q09472) Pfam (PF00439) | Homo sapiens (Human) | p300 HAT,E1A-associated protein p300, EP300 |
| 2 | B (A) | 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole | non-polymer | 509.0 | 1 | Chemie (2LO) | |||
| 3 | C (A) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 1 | Chemie (IPA) | |||
| 4 | D (A) | water | water | 18.0 | 189 | Chemie (HOH) |
Sequence modifications
A: 1048 - 1161 (UniProt: Q09472)
| PDB | External Database | Details |
|---|---|---|
| Ser 1046 | - | expression tag |
| Met 1047 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13826.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 569.1 | |
| All* | Total formula weight | 14395.9 |
