5BRM
Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | MOB kinase activator 1A | polymer | 177 | 20724.8 | 6 | UniProt (Q9H8S9) Pfam (PF03637) In PDB | Homo sapiens (Human) | Mob1 alpha,Mob1A,Mob1 homolog 1B,Mps one binder kinase activator-like 1B |
| 2 | G, H, I, J, K... | Serine/threonine-protein kinase 3 | polymer | 31 | 3778.9 | 9 | UniProt (Q13188) In PDB | Homo sapiens | Mammalian STE20-like protein kinase 2,MST-2,STE20-like kinase MST2,Serine/threonine-protein kinase Krs-1 |
| 3 | A, B, C, D, E... | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 4 | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 41 - 216 (UniProt: Q9H8S9)
| PDB | External Database | Details |
|---|---|---|
| Gly 40 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 158358.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 392.5 | |
| All* | Total formula weight | 158751.0 |
