5BRM
Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 301 |
| Chain | Residue |
| A | CYS79 |
| A | CYS84 |
| A | HIS161 |
| A | HIS166 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 301 |
| Chain | Residue |
| B | CYS79 |
| B | CYS84 |
| B | HIS161 |
| B | HIS166 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 301 |
| Chain | Residue |
| C | CYS84 |
| C | HIS161 |
| C | HIS166 |
| C | CYS79 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 301 |
| Chain | Residue |
| D | CYS79 |
| D | CYS84 |
| D | HIS161 |
| D | HIS166 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 301 |
| Chain | Residue |
| E | CYS79 |
| E | CYS84 |
| E | HIS161 |
| E | HIS166 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 301 |
| Chain | Residue |
| F | CYS79 |
| F | CYS84 |
| F | HIS161 |
| F | HIS166 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:29063833, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| G | TPO378 | |
| H | TPO378 | |
| I | TPO378 | |
| J | TPO378 | |
| K | TPO378 | |
| L | TPO378 | |
| M | TPO378 | |
| N | TPO378 | |
| O | TPO378 | |
| C | CYS84 | |
| C | HIS161 | |
| C | HIS166 | |
| D | CYS79 | |
| D | CYS84 | |
| D | HIS161 | |
| D | HIS166 | |
| E | CYS79 | |
| E | CYS84 | |
| E | HIS161 | |
| E | HIS166 | |
| F | CYS79 | |
| F | CYS84 | |
| F | HIS161 | |
| F | HIS166 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:20086174 |
| Chain | Residue | Details |
| G | THR384 | |
| H | THR384 | |
| I | THR384 | |
| J | THR384 | |
| K | THR384 | |
| L | THR384 | |
| M | THR384 | |
| N | THR384 | |
| O | THR384 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| M | SER385 | |
| N | SER385 | |
| O | SER385 | |
| G | SER385 | |
| H | SER385 | |
| I | SER385 | |
| J | SER385 | |
| K | SER385 | |
| L | SER385 |
