5BPK

Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Gamma-glutamyltranspeptidase (Ggt)	polymer	379	40832.0	2	UniProt (O25743) Pfam (PF01019) In PDB	Helicobacter pylori 26695
2	C, D	Gamma-glutamyltranspeptidase (Ggt)	polymer	225	24557.6	2	UniProt (O25743) Pfam (PF01019) In PDB	Helicobacter pylori 26695
3	B, A, D, C	1,2-ETHANEDIOL	non-polymer		62.1	43	Chemie (EDO)
4	D, C	(2S)-amino[(5S)-4,5-dihydro-1,2-oxazol-5-yl]acetic acid	non-polymer		144.1	2	Chemie (4UD)	Helicobacter pylori
5		water	water		18.0	958	Chemie (HOH)

Sequence modifications

C, D: 380 - 567 (UniProt: O25743)

PDB	External Database	Details
Gly 568	-	expression tag
Thr 569	-	expression tag
Gly 570	-	expression tag
Ser 571	-	expression tag
Lys 572	-	expression tag
Leu 573	-	expression tag
Ala 574	-	expression tag
Ala 575	-	expression tag
Ala 576	-	expression tag
Gln 577	-	expression tag
Leu 578	-	expression tag
Tyr 579	-	expression tag
Thr 580	-	expression tag
Arg 581	-	expression tag
Ala 582	-	expression tag
Ser 583	-	expression tag
Gln 584	-	expression tag
Pro 585	-	expression tag
Glu 586	-	expression tag
Leu 587	-	expression tag
Ala 588	-	expression tag
Pro 589	-	expression tag
Glu 590	-	expression tag
Asp 591	-	expression tag
Pro 592	-	expression tag
Glu 593	-	expression tag
Asp 594	-	expression tag
Leu 595	-	expression tag
Glu 596	-	expression tag
His 597	-	expression tag
His 598	-	expression tag
His 599	-	expression tag
His 600	-	expression tag
His 601	-	expression tag
His 602	-	expression tag
His 603	-	expression tag
His 604	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	130779.4
Non-Polymers*	Number of molecules	45
	Total formula weight	2957.2
All*	Total formula weight	133736.5

*Water molecules are not included.