5BOQ
Human insulin with intra-chain chemical crosslink between modified B24 and B29
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Insulin | polymer | 21 | 2383.7 | 4 | UniProt (P01308) | Homo sapiens | |
| 2 | B, D, F, H (B, D, F, H) | Insulin | polymer | 30 | 3408.9 | 4 | UniProt (P01308) Pfam (PF00049) | Homo sapiens | |
| 3 | I, J, K (A, C) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | L, M, N, O, P... (A, B, C, D, E...) | water | water | 18.0 | 200 | Chemie (HOH) |
Sequence modifications
B, D, F, H: 1 - 30 (UniProt: P01308)
| PDB | External Database | Details |
|---|---|---|
| Hix 24 | Phe 48 | engineered mutation |
| Nle 29 | Lys 53 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 23170.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 288.2 | |
| All* | Total formula weight | 23458.5 |
