5BO8
Structure of human sialyltransferase ST8SiaIII
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase | polymer | 343 | 40127.5 | 2 | UniProt (O43173) Pfam (PF00777) | Homo sapiens (Human) | Alpha-2,8-sialyltransferase 8C,8-sialyltransferase III,ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3,Sialyltransferase 8C,SIAT8-C,Sialyltransferase St8Sia III,ST8SiaIII |
| 2 | C, D, E, H, I (C, D, E, H, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 3 | F (F) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 4 | G (G) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 5 | J (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | K (B) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 7 | L, M (A, B) | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A, B: 61 - 380 (UniProt: O43173)
| PDB | External Database | Details |
|---|---|---|
| Ala 38 | - | expression tag |
| Pro 39 | - | expression tag |
| Glu 40 | - | expression tag |
| His 41 | - | expression tag |
| His 42 | - | expression tag |
| His 43 | - | expression tag |
| His 44 | - | expression tag |
| His 45 | - | expression tag |
| His 46 | - | expression tag |
| Asp 47 | - | expression tag |
| Tyr 48 | - | expression tag |
| Asp 49 | - | expression tag |
| Ile 50 | - | expression tag |
| Pro 51 | - | expression tag |
| Thr 52 | - | expression tag |
| Thr 53 | - | expression tag |
| Glu 54 | - | expression tag |
| Asn 55 | - | expression tag |
| Leu 56 | - | expression tag |
| Tyr 57 | - | expression tag |
| Phe 58 | - | expression tag |
| Gln 59 | - | expression tag |
| Gly 60 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80255.1 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 3603.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 413.3 | |
| All* | Total formula weight | 84271.8 |
