5BO2
Bianthranilate-like inhibitor with 4-atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Anthranilate phosphoribosyltransferase | polymer | 379 | 38948.0 | 2 | UniProt (A5U4M0) Pfam (PF02885) Pfam (PF00591) | Mycobacterium tuberculosis | |
| 2 | C, F (A, B) | 2-[(2-carboxyphenyl)amino]-5-(3-phosphonopropoxy)benzoic acid | non-polymer | 395.3 | 2 | Chemie (7P1) | |||
| 3 | D, E, G, H, I (A, B) | IMIDAZOLE | non-polymer | 69.1 | 5 | Chemie (IMD) | |||
| 4 | J, K (A, B) | water | water | 18.0 | 352 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 370 (UniProt: A5U4M0)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Val 1 | - | expression tag |
| Leu 371 | - | expression tag |
| Glu 372 | - | expression tag |
| His 373 | - | expression tag |
| His 374 | - | expression tag |
| His 375 | - | expression tag |
| His 376 | - | expression tag |
| His 377 | - | expression tag |
| His 378 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77896.0 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1136.0 | |
| All* | Total formula weight | 79032.0 |
