5BO2
Bianthranilate-like inhibitor with 4-atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004048 | molecular_function | anthranilate phosphoribosyltransferase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000162 | biological_process | L-tryptophan biosynthetic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004048 | molecular_function | anthranilate phosphoribosyltransferase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue 7P1 A 400 |
| Chain | Residue |
| A | HIS91 |
| A | ARG187 |
| A | ALA190 |
| A | ARG193 |
| A | ARG194 |
| A | GLY206 |
| A | IMD401 |
| A | IMD402 |
| A | IMD402 |
| A | HOH503 |
| A | HOH513 |
| A | ASN138 |
| A | HOH561 |
| A | HOH577 |
| A | ALA179 |
| A | PRO180 |
| A | PRO180 |
| A | ARG181 |
| A | HIS183 |
| A | PRO184 |
| A | TYR186 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue IMD A 401 |
| Chain | Residue |
| A | ASP159 |
| A | ARG181 |
| A | 7P1400 |
| A | IMD402 |
| A | IMD402 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue IMD A 402 |
| Chain | Residue |
| A | ASP159 |
| A | ASP159 |
| A | PHE178 |
| A | 7P1400 |
| A | 7P1400 |
| A | IMD401 |
| A | IMD401 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue 7P1 B 400 |
| Chain | Residue |
| A | THR257 |
| A | ARG283 |
| B | MET86 |
| B | ASN138 |
| B | ALA179 |
| B | PRO180 |
| B | HIS183 |
| B | TYR186 |
| B | ARG187 |
| B | ALA190 |
| B | ARG193 |
| B | IMD403 |
| B | HOH526 |
| B | HOH530 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue IMD B 401 |
| Chain | Residue |
| B | ALA46 |
| B | TRP47 |
| B | ASP50 |
| B | GLU342 |
| B | ARG346 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue IMD B 402 |
| Chain | Residue |
| B | ALA236 |
| B | ARG237 |
| B | LEU305 |
| B | GLY306 |
| B | GLY307 |
| B | ILE351 |
| B | ASP352 |
| B | GLU357 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue IMD B 403 |
| Chain | Residue |
| B | HIS136 |
| B | GLY206 |
| B | 7P1400 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00211","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
