5BNQ

Crystal structure of hRANKL-mRANK complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tumor necrosis factor ligand superfamily member 11	polymer	160	18054.2	1	UniProt (O14788) Pfam (PF00229) In PDB	Homo sapiens (Human)	Osteoclast differentiation factor,ODF,Osteoprotegerin ligand,OPGL,Receptor activator of nuclear factor kappa-B ligand,RANKL,TNF-related activation-induced cytokine,TRANCE
2	R	Tumor necrosis factor receptor superfamily member 11A	polymer	216	24018.1	1	UniProt (O35305) Pfam (PF00020) Pfam (PF18278) In PDB	Mus musculus (House Mouse)	Osteoclast differentiation factor receptor,ODFR,Receptor activator of NF-KB, RANK
3	A, R	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
4	A, R	CHLORIDE ION	non-polymer		35.5	8	Chemie (CL)
5	R	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6		water	water		18.0	79	Chemie (HOH)

Sequence modifications

R: 26 - 210 (UniProt: O35305)

PDB	External Database	Details
Met 3	-	initiating methionine
Gly 4	-	expression tag
Ser 5	-	expression tag
Ser 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
Ser 13	-	expression tag
Ser 14	-	expression tag
Gly 15	-	expression tag
Leu 16	-	expression tag
Val 17	-	expression tag
Pro 18	-	expression tag
Arg 19	-	expression tag
Gly 20	-	expression tag
Ser 21	-	expression tag
His 22	-	expression tag
Met 23	-	expression tag
His 24	-	expression tag
Met 25	-	expression tag
Leu 211	-	expression tag
Glu 212	-	expression tag
His 213	-	expression tag
His 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	42072.3
Non-Polymers*	Number of molecules	13
	Total formula weight	686.5
All*	Total formula weight	42758.8

*Water molecules are not included.