5B3J
Activation of NMDA receptors and the mechanism of inhibition by ifenprodil
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NMDA glutamate receptor subunit | polymer | 383 | 42932.1 | 2 | UniProt (Q91977) Pfam (PF01094) UniProt (by SIFTS) (A0A1L8F5J9) | Xenopus laevis (African clawed frog) | |
| 2 | C, E (C, D) | Glutamate receptor ionotropic, NMDA 2B | polymer | 364 | 41367.9 | 2 | UniProt (Q00960) Pfam (PF01094) | Rattus norvegicus (Rat) | GluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NR2B |
| 3 | D, G (E, H) | Fab, heavy chain | polymer | 224 | 23914.8 | 2 | Mus musculus | ||
| 4 | F, H (F, L) | Fab, light chain | polymer | 213 | 23675.2 | 2 | Mus musculus | ||
| 5 | I (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | J, K, L, M, N... (A, B, C, E, D...) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A, B: 23 - 405 (UniProt: Q91977)
C, D: 31 - 394 (UniProt: Q00960)
| PDB | External Database | Details |
|---|---|---|
| Gln 61 | Asn 61 | engineered mutation |
| Gln 371 | Asn 371 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asp 348 | Asn 348 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 263779.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 23.0 | |
| All* | Total formula weight | 263802.8 |
