5B3J

Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	NMDA glutamate receptor subunit	polymer	383	42932.1	2	UniProt (Q91977) Pfam (PF01094) UniProt (by SIFTS) (A0A1L8F5J9) In PDB	Xenopus laevis (African clawed frog)
2	C, D	Glutamate receptor ionotropic, NMDA 2B	polymer	364	41367.9	2	UniProt (Q00960) Pfam (PF01094) In PDB	Rattus norvegicus (Rat)	GluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NR2B
3	E, H	Fab, heavy chain	polymer	224	23914.8	2		Mus musculus
4	F, L	Fab, light chain	polymer	213	23675.2	2		Mus musculus
5	B	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6		water	water		18.0	107	Chemie (HOH)

Sequence modifications

A, B: 23 - 405 (UniProt: Q91977)

PDB	External Database	Details
Gln 61	Asn 61	engineered mutation
Gln 371	Asn 371	engineered mutation

C, D: 31 - 394 (UniProt: Q00960)

PDB	External Database	Details
Asp 348	Asn 348	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	263779.8
Non-Polymers*	Number of molecules	1
	Total formula weight	23.0
All*	Total formula weight	263802.8

*Water molecules are not included.