5AZ5
Crystal structure of human TLR8 in complex with MB-343
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Toll-like receptor 8 | polymer | 811 | 92835.4 | 4 | UniProt (Q9NR97) Pfam (PF13855) In PDB | Homo sapiens (Human) | |
2 | E, G, H | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
3 | F, I, L, O | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
4 | J, K, N, P | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
5 | M | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
6 | C, A | 1-pentyl-4-phenyl-imidazol-2-amine | non-polymer | 229.3 | 4 | Chemie (MBL) | |||
7 | C, D, A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 14 | Chemie (NAG) | |||
8 | water | water | 18.0 | 291 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 27 - 827 (UniProt: Q9NR97)
PDB | External Database | Details |
---|---|---|
Arg 23 | - | expression tag |
Ser 24 | - | expression tag |
Pro 25 | - | expression tag |
Trp 26 | - | expression tag |
Glu 828 | - | expression tag |
Phe 829 | - | expression tag |
Leu 830 | - | expression tag |
Val 831 | - | expression tag |
Pro 832 | - | expression tag |
Arg 833 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 371341.5 | |
Branched | Number of molecules | 12 |
Total formula weight | 7038.5 | |
Non-Polymers* | Number of molecules | 18 |
Total formula weight | 4014.2 | |
All* | Total formula weight | 382394.2 |