5AYF
Crystal structure of SET7/9 in complex with cyproheptadine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase SETD7 | polymer | 263 | 28864.2 | 1 | UniProt (Q8WTS6) Pfam (PF22648) Pfam (PF00856) | Homo sapiens (Human) | Histone H3-K4 methyltransferase SETD7,H3-K4-HMTase SETD7,Lysine N-methyltransferase 7,SET domain-containing protein 7,SET7/9 |
| 2 | B (A) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (9865603) PubChem (145712080) PubChem (12312798) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) | |||
| 3 | C (A) | 4-(dibenzo[1,2-a:2',1'-d][7]annulen-11-ylidene)-1-methyl-piperidine | non-polymer | 287.4 | 1 | Chemie (C7H) PubChem (2913) | |||
| 4 | D (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) PubChem (3777159) | |||
| 5 | E (A) | water | water | 18.0 | 179 | Chemie (HOH) |
Sequence modifications
A: 111 - 366 (UniProt: Q8WTS6)
| PDB | External Database | Details |
|---|---|---|
| Gly 104 | - | expression tag |
| Ser 105 | - | expression tag |
| Ser 106 | - | expression tag |
| Gly 107 | - | expression tag |
| Ser 108 | - | expression tag |
| Ser 109 | - | expression tag |
| Gly 110 | - | expression tag |
| Unk 337 | Tyr 337 | see sequence details |
| Unk 338 | Asp 338 | see sequence details |
| Unk 339 | His 339 | see sequence details |
| Unk 340 | Ser 340 | see sequence details |
| Unk 341 | Pro 341 | see sequence details |
| Unk 342 | Pro 342 | see sequence details |
| Unk 343 | Gly 343 | see sequence details |
| Unk 344 | Lys 344 | see sequence details |
| Unk 345 | Ser 345 | see sequence details |
| Unk 346 | Gly 346 | see sequence details |
| Unk 347 | Pro 347 | see sequence details |
| Unk 348 | Glu 348 | see sequence details |
| Unk 349 | Ala 349 | see sequence details |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28864.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 808.0 | |
| All* | Total formula weight | 29672.2 |
