5AYF

Crystal structure of SET7/9 in complex with cyproheptadine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Histone-lysine N-methyltransferase SETD7	polymer	263	28864.2	1	UniProt (Q8WTS6) Pfam (PF22648) Pfam (PF00856)	Homo sapiens (Human)	Histone H3-K4 methyltransferase SETD7,H3-K4-HMTase SETD7,Lysine N-methyltransferase 7,SET domain-containing protein 7,SET7/9
2	B (A)	S-ADENOSYLMETHIONINE	non-polymer		398.4	1	Chemie (SAM)
3	C (A)	4-(dibenzo[1,2-a:2',1'-d][7]annulen-11-ylidene)-1-methyl-piperidine	non-polymer		287.4	1	Chemie (C7H)
4	D (A)	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		122.1	1	Chemie (TRS)
5	E (A)	water	water		18.0	179	Chemie (HOH)

Sequence modifications

A: 111 - 366 (UniProt: Q8WTS6)

PDB	External Database	Details
Gly 104	-	expression tag
Ser 105	-	expression tag
Ser 106	-	expression tag
Gly 107	-	expression tag
Ser 108	-	expression tag
Ser 109	-	expression tag
Gly 110	-	expression tag
Unk 337	Tyr 337	see sequence details
Unk 338	Asp 338	see sequence details
Unk 339	His 339	see sequence details
Unk 340	Ser 340	see sequence details
Unk 341	Pro 341	see sequence details
Unk 342	Pro 342	see sequence details
Unk 343	Gly 343	see sequence details
Unk 344	Lys 344	see sequence details
Unk 345	Ser 345	see sequence details
Unk 346	Gly 346	see sequence details
Unk 347	Pro 347	see sequence details
Unk 348	Glu 348	see sequence details
Unk 349	Ala 349	see sequence details

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	28864.2
Non-Polymers*	Number of molecules	3
	Total formula weight	808.0
All*	Total formula weight	29672.2

*Water molecules are not included.