5AXP

Crystal structure of the catalytic domain of PDE10A complexed with 1-(2-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	polymer	338	38889.6	2	UniProt (Q9Y233)	Homo sapiens (Human)
2	C, F (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	D, G (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	E, H (A, B)	3-[3-fluoranyl-4-[5-methoxy-4-oxidanylidene-3-(2-phenylpyrazol-3-yl)pyridazin-1-yl]phenyl]-1,3-oxazolidin-2-one	non-polymer		447.4	2	Chemie (4LK)
5	I, J (A, B)	water	water		18.0	313	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	77779.2
Non-Polymers*	Number of molecules	6
	Total formula weight	1074.3
All*	Total formula weight	78853.4

*Water molecules are not included.