5AWJ
Crystal structure of VDR-LBD/partial agonist complex: 22S-hexyl analogue
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vitamin D3 receptor,Vitamin D3 receptor | polymer | 271 | 30595.0 | 1 | UniProt (P13053) Pfam (PF00104) | Rattus norvegicus (Rat) | VDR,1,25-dihydroxyvitamin D3 receptor,Nuclear receptor subfamily 1 group I member 1,VDR,1,25-dihydroxyvitamin D3 receptor,Nuclear receptor subfamily 1 group I member 1 |
| 2 | B (C) | Mediator of RNA polymerase II transcription subunit 1 | polymer | 13 | 1570.9 | 1 | UniProt (Q15648) | Homo sapiens | |
| 3 | C (A) | (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3S)-3-(2-hydroxyethyl)nonan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidene-cyclohexane-1,3-diol | non-polymer | 458.7 | 1 | Chemie (YSL) | |||
| 4 | D, E (A, C) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A: 116 - 211 (UniProt: P13053)
A: 212 - 423 (UniProt: P13053)
| PDB | External Database | Details |
|---|---|---|
| Gly 106 | - | expression tag |
| Ser 107 | - | expression tag |
| His 108 | - | expression tag |
| Met 109 | - | expression tag |
| Gly 110 | - | expression tag |
| Ser 111 | - | expression tag |
| Pro 112 | - | expression tag |
| Asn 113 | - | expression tag |
| Ser 114 | - | expression tag |
| Pro 115 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32165.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 458.7 | |
| All* | Total formula weight | 32624.7 |
