5AMN
The Discovery of 2-Substituted Phenol Quinazolines as Potent and Selective RET Kinase Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET | polymer | 299 | 34353.6 | 1 | UniProt (P07949) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | CADHERIN FAMILY MEMBER 12, PROTO-ONCOGENE C-RET |
| 2 | A | 4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE | non-polymer | 297.3 | 1 | Chemie (DTQ) | |||
| 3 | A | FORMIC ACID | non-polymer | 46.0 | 7 | Chemie (FMT) | |||
| 4 | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A: 705 - 826 (UniProt: P07949)
| PDB | External Database | Details |
|---|---|---|
| Gly 700 | - | expression tag |
| Pro 701 | - | expression tag |
| Leu 702 | - | expression tag |
| Ser 703 | - | expression tag |
| Leu 704 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34353.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 619.5 | |
| All* | Total formula weight | 34973.1 |
