5AMN

The Discovery of 2-Substituted Phenol Quinazolines as Potent and Selective RET Kinase Inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FMT A 2011

Chain	Residue
A	GLY700
A	PRO701
A	LEU702
A	SER703
A	GLN910
A	LEU923
A	PHE924
A	HIS926

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 2012

Chain	Residue
A	LEU895
A	LYS907
A	GLY911
A	ARG912
A	ARG873

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 2013

Chain	Residue
A	ASP707
A	LYS728
A	LYS740
A	TYR806

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 2014

Chain	Residue
A	HOH3039

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 2015

Chain	Residue
A	ALA866
A	VAL997
A	PHE998
A	ALA999

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site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE FMT A 2016

Chain	Residue
A	LYS747

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site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FMT A 2017

Chain	Residue
A	THR754
A	PHE924
A	HOH3009

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGEFGKVVkAtafhlkgragytt.....VAVK

Chain	Residue	Details
A	LEU730-LYS758

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNILV

Chain	Residue	Details
A	LEU870-VAL882

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP874

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU730
A	LYS758

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:20117004, ECO:0007744|PDB:2X2M

Chain	Residue	Details
A	GLU805

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by caspase-3

Chain	Residue	Details
A	ASP707

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Breakpoint for translocation to form PCM1-RET; RET-CCDC6; RET-GOLGA5; RET-TRIM24 and RET-TRIM33 oncogenes

Chain	Residue	Details
A	LEU712

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site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:14711813

Chain	Residue	Details
A	TYR806
A	TYR809
A	TYR981

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:14711813, ECO:0000269|PubMed:16928683

Chain	Residue	Details
A	PTR900

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site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:14711813, ECO:0000269|PubMed:16928683, ECO:0000269|PubMed:20117004, ECO:0000269|PubMed:28846099

Chain	Residue	Details
A	PTR905

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