5AB2

Crystal structure of aminopeptidase ERAP2 with ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2	polymer	967	111578.5	2	UniProt (Q6P179) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838)	HOMO SAPIENS (HUMAN)	LEUKOCYTE-DERIVED ARGININE AMINOPEPTIDASE, L-RAP
2	C, D (C, D)	GPI	polymer	6	604.7	2		SYNTHETIC CONSTRUCT
3	E, G (E, G)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
4	F, H, I, J, K... (F, H, I, J, K...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	7	In PDB GlyTouCan (G42666HT)
5	L (L)	beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G40894EI)
6	O, P, U, V, W (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
7	Q, X (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
8	AA, R, S, T, Y... (B, A)	1,2-ETHANEDIOL	non-polymer		62.1	6	Chemie (EDO)
9	BA, CA (A, B)	water	water		18.0	102	Chemie (HOH)

Sequence modifications

A, B: 1 - 960 (UniProt: Q6P179)

PDB	External Database	Details
Arg 961	-	cloning artifact
His 962	-	expression tag
His 963	-	expression tag
His 964	-	expression tag
His 965	-	expression tag
His 966	-	expression tag
His 967	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	224366.4
Branched	Number of molecules	10
	Total formula weight	4892.6
Non-Polymers*	Number of molecules	13
	Total formula weight	1609.3
All*	Total formula weight	230868.2

*Water molecules are not included.