5AB2
Crystal structure of aminopeptidase ERAP2 with ligand
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2 | polymer | 967 | 111578.5 | 2 | UniProt (Q6P179) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) In PDB | HOMO SAPIENS (HUMAN) | LEUKOCYTE-DERIVED ARGININE AMINOPEPTIDASE, L-RAP |
2 | C, D | GPI | polymer | 6 | 604.7 | 2 | SYNTHETIC CONSTRUCT | ||
3 | E, G | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
4 | F, H, I, J, K... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 7 | In PDB GlyTouCan (G42666HT) | |||
5 | L | beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G40894EI) | |||
6 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
7 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
8 | B, A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
9 | water | water | 18.0 | 102 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 960 (UniProt: Q6P179)
PDB | External Database | Details |
---|---|---|
Arg 961 | - | cloning artifact |
His 962 | - | expression tag |
His 963 | - | expression tag |
His 964 | - | expression tag |
His 965 | - | expression tag |
His 966 | - | expression tag |
His 967 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 224366.4 | |
Branched | Number of molecules | 10 |
Total formula weight | 4892.6 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 1609.3 | |
All* | Total formula weight | 230868.2 |