5AAM

Structure of a redesigned cross-reactive antibody to dengue virus with increased in vivo potency

Replaces:  4UD3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	SCFV513	polymer	251	27299.4	2		MUS MUSCULUS (HOUSE MOUSE)
2	C, D (C, J)	ENVELOPE PROTEIN	polymer	115	12692.6	2	UniProt (U3N5N6) Pfam (PF02832) UniProt (by SIFTS) (Q6YFU0)	DENGUE VIRUS	DENGUE SEROTYPE 4 ENVELOPE PROTEIN DOMAIN III
3	E, F, G, H (A, B, C, J)	water	water		18.0	127	Chemie (HOH)

Sequence modifications

C, J: 293 - 400 (UniProt: U3N5N6)

PDB	External Database	Details
Met 292	-	expression tag
His 401	-	expression tag
His 402	-	expression tag
His 403	-	expression tag
His 404	-	expression tag
His 405	-	expression tag
His 406	-	expression tag
Leu 357	Phe 66	conflict
Asn 384	Asp 93	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	79983.8
All*	Total formula weight	79983.8

*Water molecules are not included.