5A83
Crystal structure of human ATAD2 bromodomain in complex with 4-((3R, 4R)-4-3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydroquinolin-8- yl-aminopiperidin-3-yloxymethyl)-1-thiane-1,1-dione
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2 | polymer | 130 | 15453.5 | 1 | UniProt (Q14CR1) Pfam (PF00439) UniProt (by SIFTS) (Q6PL18) In PDB | HOMO SAPIENS (HUMAN) | AAA NUCLEAR COREGULATOR CANCER-ASSOCIATED PROTEIN, ANCCA |
| 2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 3 | A | 8-[[(3R,4R)-3-[[1,1-bis(oxidanylidene)thian-4-yl]methoxy]piperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-quinolin-2-one | non-polymer | 510.6 | 1 | Chemie (YD3) | |||
| 4 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | water | water | 18.0 | 224 | Chemie (HOH) |
Sequence modifications
A: 981 - 1108 (UniProt: Q14CR1)
| PDB | External Database | Details |
|---|---|---|
| Ser 979 | - | expression tag |
| Met 980 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15453.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 889.0 | |
| All* | Total formula weight | 16342.5 |
