5A83
Crystal structure of human ATAD2 bromodomain in complex with 4-((3R, 4R)-4-3-methyl-5-(5-methylpyridin-3-yl)-2-oxo-1,2-dihydroquinolin-8- yl-aminopiperidin-3-yloxymethyl)-1-thiane-1,1-dione
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006325 | biological_process | chromatin organization |
| A | 0006355 | biological_process | regulation of transcription, DNA-templated |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1109 |
| Chain | Residue |
| A | VAL1022 |
| A | ILE1025 |
| A | LYS1026 |
| A | PRO1028 |
| A | HOH2113 |
| A | HOH2127 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 1110 |
| Chain | Residue |
| A | LEU1093 |
| A | ASP1094 |
| A | HOH2191 |
| A | HOH2196 |
| A | HOH2218 |
| A | HOH2219 |
| A | HIS998 |
| A | GLU1091 |
| A | GLU1092 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1111 |
| Chain | Residue |
| A | GLU988 |
| A | LEU1093 |
| A | ASP1094 |
| A | PHE1097 |
| A | HOH2220 |
| A | HOH2221 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE YD3 A 1112 |
| Chain | Residue |
| A | VAL1013 |
| A | ASP1014 |
| A | GLU1017 |
| A | VAL1018 |
| A | TYR1063 |
| A | ASN1064 |
| A | GLY1070 |
| A | ASP1071 |
| A | ILE1074 |
| A | ARG1077 |
| A | HOH2107 |
| A | HOH2169 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1113 |
| Chain | Residue |
| A | GLN1027 |
| A | LYS1042 |
| A | HOH2128 |
| A | HOH2223 |
| A | HOH2224 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1114 |
| Chain | Residue |
| A | ARG987 |
| A | ARG990 |
| A | ARG994 |
| A | ARG1067 |
| A | ARG1072 |
| A | HOH2069 |
| A | HOH2162 |
