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5A7O

Crystal structure of human JMJD2A in complex with compound 42

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BLYSINE-SPECIFIC DEMETHYLASE 4Apolymer38144342.22UniProt (O75164)
Pfam (PF02375)
Pfam (PF02373)
In PDB
HOMO SAPIENS (HUMAN)JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 3A, JUMONJI DOMAIN-CONTAINING PROTEIN 2A
2A, BSULFATE IONnon-polymer96.12Chemie (SO4)
3A, B2-[5-(2-methoxyethanoylamino)-2-oxidanyl-phenyl]pyridine-4-carboxylic acidnon-polymer302.32Chemie (7WH)
4A, B1,2-ETHANEDIOLnon-polymer62.116Chemie (EDO)
5A, BZINC IONnon-polymer65.42Chemie (ZN)
6B, AMANGANESE (II) IONnon-polymer54.92Chemie (MN)
7B, ADIMETHYL SULFOXIDEnon-polymer78.12Chemie (DMS)
8waterwater18.0316Chemie (HOH)
Sequence modifications
A, B: 1 - 359 (UniProt: O75164)
PDBExternal DatabaseDetails
Met -21-expression tag
His -20-expression tag
His -19-expression tag
His -18-expression tag
His -17-expression tag
His -16-expression tag
His -15-expression tag
Ser -14-expression tag
Ser -13-expression tag
Gly -12-expression tag
Val -11-expression tag
Asp -10-expression tag
Leu -9-expression tag
Gly -8-expression tag
Thr -7-expression tag
Glu -6-expression tag
Asn -5-expression tag
Leu -4-expression tag
Tyr -3-expression tag
Phe -2-expression tag
Gln -1-expression tag
Ser 0-expression tag
Glu 354Leu 354conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight88684.5
Non-Polymers*Number of molecules26
Total formula weight2186.7
All*Total formula weight90871.2
*Water molecules are not included.

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PDB entries from 2024-03-27

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