5A5T
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A | polymer | 1362 | 164902.7 | 1 | UniProt (G1SMZ5) Pfam (PF22591) Pfam (PF01399) | ORYCTOLAGUS CUNICULUS (RABBIT) | EIF3A, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 10, EIF-3-THETA |
| 2 | B (C) | EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C | polymer | 843 | 97923.5 | 1 | UniProt (G1U971) Pfam (PF05470) Pfam (PF01399) | ORYCTOLAGUS CUNICULUS (RABBIT) | EIF3C, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 8, EIF3 P110 |
| 3 | C (E) | EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E | polymer | 445 | 52281.6 | 1 | UniProt (G1SUC8) Pfam (PF09440) Pfam (PF01399) Pfam (PF21357) | ORYCTOLAGUS CUNICULUS (RABBIT) | EIF3E, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 6, EIF-3 P48 |
| 4 | D (F) | EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F | polymer | 364 | 37846.7 | 1 | UniProt (U3KNL5) | ORYCTOLAGUS CUNICULUS (RABBIT) | EIF3F, DEUBIQUITINATING ENZYME EIF3F, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 5, EIF-3-EPSILON, EIF3 P47 |
| 5 | E (H) | EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT H | polymer | 352 | 39952.3 | 1 | UniProt (G1ST95) Pfam (PF01398) Pfam (PF19445) | ORYCTOLAGUS CUNICULUS (RABBIT) | EIF3H, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 3, EIF-3-GAMMA, EIF3 P40 SUBUNIT |
| 6 | F (K) | EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K | polymer | 218 | 25129.7 | 1 | UniProt (G1T3L2) Pfam (PF10075) | ORYCTOLAGUS CUNICULUS (RABBIT) | EIF3K, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 12, EIF-3 P25 |
| 7 | G (L) | UNCHARACTERIZED PROTEIN | polymer | 564 | 66804.8 | 1 | UniProt (G1SED9) Pfam (PF10255) | ORYCTOLAGUS CUNICULUS (RABBIT) | |
| 8 | H (M) | EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M | polymer | 374 | 42555.8 | 1 | UniProt (G1SLW8) Pfam (PF01399) Pfam (PF18005) | ORYCTOLAGUS CUNICULUS (RABBIT) | EIF3M, FETAL LUNG PROTEIN B5, HFL-B5, PCI DOMAIN-CONTAINING PROTEIN 1 |
Sequence modifications
C: 71 - 913 (UniProt: G1U971)
| PDB | External Database | Details |
|---|---|---|
| Tyr 577 | Ala 577 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 527397.2 | |
| All* | Total formula weight | 527397.2 |
