5A3U
HIF prolyl hydroxylase 2 (PHD2/EGLN1) in complex with 6-(5-oxo-4-(1H- 1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | EGL NINE HOMOLOG 1 | polymer | 252 | 28096.9 | 3 | UniProt (Q9GZT9) Pfam (PF13640) | HOMO SAPIENS (HUMAN) | HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2, HIF-PH2, HIF-PROLYL HYDROXYLASE 2, HPH-2, PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2, PHD2, SM-20, HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE 2 |
| 2 | D, F, H (A, B, C) | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) | |||
| 3 | E, G, I (A, B, C) | 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinic acid | non-polymer | 272.2 | 3 | Chemie (R8J) |
Sequence modifications
A, B, C: 181 - 426 (UniProt: Q9GZT9)
| PDB | External Database | Details |
|---|---|---|
| Gly 175 | - | expression tag |
| Ser 176 | - | expression tag |
| His 177 | - | expression tag |
| Met 178 | - | expression tag |
| Ala 179 | - | expression tag |
| Ser 180 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 84290.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 981.5 | |
| All* | Total formula weight | 85272.3 |
